NFL Straight-Up Moneyline Picks for Every Game in Week 11

SI Staff | Nov 12, 2025

The SI Team makes their picks for Week 11 of the 2025 NFL Season. / Sports Illustrated

It was a successful week of picks for the SI Team in Week 10, with seven of the eight panelists putting together a profitable week. Conor Orr continues to crush this season's picks, sitting well ahead of the rest at 99-49-1 for +13.54 units.

It's time to move on to Week 11 of the 2025 NFL season. The team has its picks locked in for Week 12, so let's jump into them.

Week 10 Results

• Clare Brennan, Associate Editor 9-5 (+0.78 units)
• Mitch Goldich, Senior Editor 9-5 (+0.02 units)
• Gilberto Manzano, NFL Staff Writer 11-3 (+3.83 units)
• Conor Orr, Senior Writer 10-4 (+2.43 units)
• John Pluym, NFL Managing Editor 9-5 (+0.88 units)
• Matt Verderame, NFL Staff Writer 9-5 (-0.33 units)
• Iain MacMillan, Senior Editor, Betting 9-5 (+1.15 units)
• Peter Dewey, Associate Managing Editor, Betting 6-8 (-2.18 units)

Season-to-Date Results

• Clare Brennan, Associate Editor 95-53-1 (-3.59 units)
• Mitch Goldich, Senior Editor 95-53-1 (-3.87 units)
• Gilberto Manzano, NFL Staff Writer 86-72 (-14.97 units)
• Conor Orr, Senior Writer 99-49-1 (+13.54 units)
• John Pluym, NFL Managing Editor 90-58-1 (-11.36 units)
• Matt Verderame, NFL Staff Writer 100-48-1 (+4.14 units)
• Iain MacMillan, Senior Editor, Betting 86-62-1 (-11.04 units)
• Peter Dewey, Associate Managing Editor, Betting 94-55-1 (-6.33 units)

NFL Week 11 Picks

SI NFL moneyline picks for Week 11. / Sports Illustrated

All odds are via DraftKings Sportsbook

Jets (+600) vs. Patriots (-900)

• Clare Brennan: Patriots
• Mitch Goldich: Patriots
• Gilberto Manzano: Patriots
• Conor Orr: Patriots
• John Pluym: Patriots
• Matt Verderame: Patriots
• Iain MacMillan: Patriots
• Peter Dewey: Patriots

Commanders (+124) vs. Dolphins (-148)

• Clare Brennan: Dolphins
• Mitch Goldich: Dolphins
• Gilberto Manzano: Dolphins
• Conor Orr: Dolphins
• John Pluym: Dolphins
• Matt Verderame: Dolphins
• Iain MacMillan: Dolphins
• Peter Dewey: Dolphins

Bengals (+195) vs. Steelers (-238)

• Clare Brennan: Steelers
• Mitch Goldich: Bengals
• Gilberto Manzano: Bengals
• Conor Orr: Steelers
• John Pluym: Steelers
• Matt Verderame: Steelers
• Iain MacMillan: Steelers
• Peter Dewey: Bengals

Chargers (-155) vs. Jaguars (+130)

• Clare Brennan: Chargers
• Mitch Goldich: Chargers
• Gilberto Manzano: Chargers
• Conor Orr: Chargers
• John Pluym: Jaguars
• Matt Verderame: Jaguars
• Iain MacMillan: Chargers
• Peter Dewey: Chargers

Buccaneers (+205) vs. Bills (-250)

• Clare Brennan: Bills
• Mitch Goldich: Bills
• Gilberto Manzano: Bills
• Conor Orr: Bills
• John Pluym: Bills
• Matt Verderame: Bills
• Iain MacMillan: Bills
• Peter Dewey: Buccaneers

Bears (+150) vs. Vikings (-180)

• Clare Brennan: Bears
• Mitch Goldich: Vikings
• Gilberto Manzano: Bears
• Conor Orr: Vikings
• John Pluym: Bears
• Matt Verderame: Vikings
• Iain MacMillan: Vikings
• Peter Dewey: Bears

Texans (-340) vs. Titans (+270)

• Clare Brennan: Texans
• Mitch Goldich: Texans
• Gilberto Manzano: Texans
• Conor Orr: Texans
• John Pluym: Texans
• Matt Verderame: Texans
• Iain MacMillan: Texans
• Peter Dewey: Texans

Panthers (+154) vs. Falcons (-185)

• Clare Brennan: Panthers
• Mitch Goldich: Panthers
• Gilberto Manzano: Falcons
• Conor Orr: Falcons
• John Pluym: Falcons
• Matt Verderame: Falcons
• Iain MacMillan: Falcons
• Peter Dewey: Panthers

Packers (-375) vs. Giants (+295)

• Clare Brennan: Packers
• Mitch Goldich: Packers
• Gilberto Manzano: Packers
• Conor Orr: Packers
• John Pluym: Packers
• Matt Verderame: Packers
• Iain MacMillan: Packers
• Peter Dewey: Packers

Seahawks (+136) vs. Rams (-162)

• Clare Brennan: Rams
• Mitch Goldich: Seahawks
• Gilberto Manzano: Rams
• Conor Orr: Rams
• John Pluym: Seahawks
• Matt Verderame: Rams
• Iain MacMillan: Seahawks
• Peter Dewey: Rams

49ers (-166) vs. Cardinals (+140)

• Clare Brennan: 49ers
• Mitch Goldich: 49ers
• Gilberto Manzano: Cardinals
• Conor Orr: 49ers
• John Pluym: 49ers
• Matt Verderame: 49ers
• Iain MacMillan: Cardinals
• Peter Dewey: 49ers

Ravens (-425) vs. Browns (+330)

• Clare Brennan: Ravens
• Mitch Goldich: Ravens
• Gilberto Manzano: Ravens
• Conor Orr: Ravens
• John Pluym: Ravens
• Matt Verderame: Ravens
• Iain MacMillan: Ravens
• Peter Dewey: Ravens

Chiefs (-205) vs. Broncos (+170)

• Clare Brennan: Chiefs
• Mitch Goldich: Chiefs
• Gilberto Manzano: Chiefs
• Conor Orr: Broncos
• John Pluym: Chiefs
• Matt Verderame: Chiefs
• Iain MacMillan: Chiefs
• Peter Dewey: Chiefs

Lions (+130) vs. Eagles (-155)

• Clare Brennan: Lions
• Mitch Goldich: Eagles
• Gilberto Manzano: Lions
• Conor Orr: Lions
• John Pluym: Eagles
• Matt Verderame: Eagles
• Iain MacMillan: Lions
• Peter Dewey: Eagles

Cowboys (-180) vs. Raiders (+150)

• Clare Brennan: Cowboys
• Mitch Goldich: Cowboys
• Gilberto Manzano: Cowboys
• Conor Orr: Cowboys
• John Pluym: Cowboys
• Matt Verderame: Cowboys
• Iain MacMillan: Cowboys
• Peter Dewey: Cowboys

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