NFL Straight-Up Moneyline Picks for Every Game in Week 12

Iain MacMillan | Nov 19, 2025

The Sports Illustrated team gives their picks for all 14 games in Week 12 of the 2024 NFL season. / Sports Illustrated

After weeks of having just two members of the SI Team sporting a profitable record with their picks so far this NFL season, Clare Brennan has joined as a third profitable picker. She had a strong 12-3 in Week 11 to bring her season-to-date record back into the green.

It's time to move on to Week 12 of the 2025 NFL season. The team has its picks locked in, so let's dive into them.

Week 11 Results

• Clare Brennan, Associate Editor 12-3 (+4.22 units)
• Mitch Goldich, Senior Editor 10-5 (+0.33 units)
• Gilberto Manzano, NFL Staff Writer 9-6 (-1.34 units)
• Conor Orr, Senior Writer 11-4 (+1.88 units)
• John Pluym, NFL Managing Editor 12-3 (+4.01 units)
• Matt Verderame, NFL Staff Writer 12-3 (+3.12 units)
• Iain MacMillan, Senior Editor, Betting 8-7 (-4.04 units)
• Peter Dewey, Associate Managing Editor, Betting 11-4 (+3.04 units)

Season-to-Date Results

• Clare Brennan, Associate Editor 107-56-1 (+0.63 units)
• Mitch Goldich, Senior Editor 105-58-1 (-3.54 units)
• Gilberto Manzano, NFL Staff Writer 95-78 (-16.31 units)
• Conor Orr, Senior Writer 110-53-1 (+15.42 units)
• John Pluym, NFL Managing Editor 102-61-1 (-7.35 units)
• Matt Verderame, NFL Staff Writer 109-53-1 (+7.26 units)
• Iain MacMillan, Senior Editor, Betting 94-69-1 (-15.08 units)
• Peter Dewey, Associate Managing Editor, Betting 105-59-1 (-3.29 units)

NFL Week 12 Picks

NFL Week 12 Picks / Sports Illustrated

All odds are via DraftKings Sportsbook

Bills (-278) vs. Texans (+225)

• Clare Brennan: Bills
• Mitch Goldich: Bills
• Gilberto Manzano: Bills
• Conor Orr: Bills
• John Pluym: Bills
• Matt Verderame: Bills
• Iain MacMillan: Texans
• Peter Dewey: Bills

Colts (+154) vs. Chiefs (-185)

• Clare Brennan: Colts
• Mitch Goldich: Chiefs
• Gilberto Manzano: Colts
• Conor Orr: Colts
• John Pluym: Chiefs
• Matt Verderame: Chiefs
• Iain MacMillan: Chiefs
• Peter Dewey: Chiefs

Steelers (+130) vs. Bears (-155)

• Clare Brennan: Bears
• Mitch Goldich: Bears
• Gilberto Manzano: Bears
• Conor Orr: Bears
• John Pluym: Bears
• Matt Verderame: Bears
• Iain MacMillan: Steelers
• Peter Dewey: Bears

Patriots (-440) vs. Bengals (+340)

• Clare Brennan: Patriots
• Mitch Goldich: Patriots
• Gilberto Manzano: Patriots
• Conor Orr: Patriots
• John Pluym: Patriots
• Matt Verderame: Patriots
• Iain MacMillan: Patriots
• Peter Dewey: Patriots

Jets (+600) vs. Ravens (-900)

• Clare Brennan: Ravens
• Mitch Goldich: Ravens
• Gilberto Manzano: Ravens
• Conor Orr: Ravens
• John Pluym: Ravens
• Matt Verderame: Ravens
• Iain MacMillan: Ravens
• Peter Dewey: Ravens

Seahawks (-850) vs. Titans (+575)

• Clare Brennan: Seahawks
• Mitch Goldich: Seahawks
• Gilberto Manzano: Seahawks
• Conor Orr: Seahawks
• John Pluym: Seahawks
• Matt Verderame: Seahawks
• Iain MacMillan: Seahawks
• Peter Dewey: Seahawks

Vikings (+260) vs. Packers (-325)

• Clare Brennan: Packers
• Mitch Goldich: Packers
• Gilberto Manzano: Packers
• Conor Orr: Packers
• John Pluym: Vikings
• Matt Verderame: Packers
• Iain MacMillan: Packers
• Peter Dewey: Packers

Giants (+390) vs. Lions (-520)

• Clare Brennan: Lions
• Mitch Goldich: Lions
• Gilberto Manzano: Lions
• Conor Orr: Lions
• John Pluym: Lions
• Matt Verderame: Lions
• Iain MacMillan: Lions
• Peter Dewey: Lions

Jaguars (-148) vs. Cardinals (+124)

• Clare Brennan: Jaguars
• Mitch Goldich: Jaguars
• Gilberto Manzano: Jaguars
• Conor Orr: Cardinals
• John Pluym: Jaguars
• Matt Verderame: Jaguars
• Iain MacMillan: Cardinals
• Peter Dewey: Jaguars

Browns (+145) vs. Raiders (-175)

• Clare Brennan: Raiders
• Mitch Goldich: Raiders
• Gilberto Manzano: Browns
• Conor Orr: Raiders
• John Pluym: Raiders
• Matt Verderame: Raiders
• Iain MacMillan: Raiders
• Peter Dewey: Browns

Falcons (+105) vs. Saints (-125)

• Clare Brennan: Falcons
• Mitch Goldich: Falcons
• Gilberto Manzano: Falcons
• Conor Orr: Falcons
• John Pluym: Falcons
• Matt Verderame: Falcons
• Iain MacMillan: Falcons
• Peter Dewey: Falcons

Eagles (-185) vs. Cowboys (+154)

• Clare Brennan: Eagles
• Mitch Goldich: Eagles
• Gilberto Manzano: Eagles
• Conor Orr: Cowboys
• John Pluym: Cowboys
• Matt Verderame: Eagles
• Iain MacMillan: Eagles
• Peter Dewey: Eagles

Buccaneers (+250) vs. Rams (-310)

• Clare Brennan: Rams
• Mitch Goldich: Rams
• Gilberto Manzano: Rams
• Conor Orr: Rams
• John Pluym: Buccaneers
• Matt Verderame: Rams
• Iain MacMillan: Rams
• Peter Dewey: Rams

Panthers (+275) vs. 49ers (-345)

• Clare Brennan: 49ers
• Mitch Goldich: 49ers
• Gilberto Manzano: Panthers
• Conor Orr: 49ers
• John Pluym: 49ers
• Matt Verderame: 49ers
• Iain MacMillan: 49ers
• Peter Dewey: 49ers

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