NFL Week 8 Opening Odds for Every Game (Chiefs, Chargers, Packers Open as Favorites in Primetime)

Breaking down the opening odds for every NFL game in Week 8 of the 2025 season, including the Washington Commanders vs. Kansas City Chiefs matchup on Monday night.

The Kansas City Chiefs and quarterback Patrick Mahomes are favored in Week 8. / Jay Biggerstaff-Imagn Images

The 2025 NFL season is nearing its halfway point, and Week 8 is a little bit of a lighter slate with six different teams on the bye.

The Arizona Cardinals, Detroit Lions, Jacksonville Jaguars, Las Vegas Raiders, Los Angeles Rams and Seattle Seahawks all won’t play this week, but there are some exciting primetime games to watch.

The Green Bay Packers and Pittsburgh Steelers are both hoping to show that they’re contenders in their respective conferences on Sunday night, while Patrick Mahomes and the Kansas City Chiefs will look to stay hot on Monday night against the Washington Commanders. 

There are also a bunch of divisional matchups in Week 8, including a rematch between the New York Giants and Philadelphia Eagles.

If you have an early lean for any of these games, jumping on these lines early in the week may be the way to get the best number ahead of the weekend.

Let’s dive into the opening odds for every matchup in Week 8 of the 2025 season. 

NFL Odds for Every Week 8 Game

Odds via DraftKings Sportsbook.

Thursday Night Football – Oct. 23

Minnesota Vikings vs. Los Angeles Chargers

• Spread: Chargers -2.5 (-110)
• Total: 43.5 (Over -110/Under -110)

Sunday, Oct. 26 – 1 p.m. EST Games

New York Giants vs. Philadelphia Eagles

• Spread: Eagles -7 (-110)
• Total: 44.5 (Over -105/Under -115)

New York Jets vs. Cincinnati Bengals

• Spread: Bengals -6 (-110)
• Total: 44.5 (Over -110/Under -110)

Chicago Bears vs. Baltimore Ravens

• Spread: Ravens -6 (-110)
• Total: 50.5 (Over -110/Under -110)

Miami Dolphins vs. Atlanta Falcons

• Spread: Falcons -7 (-115)
• Total: 46.5 (Over -115/Under -105)

Buffalo Bills vs. Carolina Panthers

• Spread: Bills -7 (-105)
• Total: 47.5 (Over -110/Under -110)

San Francisco 49ers vs. Houston Texans

• Spread: Texans -1.5 (-110)
• Total: 43.5 (Over -110/Under -110)

Cleveland Browns vs. New England Patriots

• Spread: Patriots -6.5 (-115)
• Total: 40.5 (Over -110/Under -110)

Sunday, Oct. 26 – 4 p.m. EST Games

Tampa Bay Buccaneers vs. New Orleans Saints

• Spread: Bucs -6.5 (-110)
• Total: 47.5 (Over -110/Under -110)

Tennessee Titans vs. Indianapolis Colts

• Spread: Colts -14 (-110)
• Total: 47.5 (Over -110/Under -110)

Dallas Cowboys vs. Denver Broncos

• Spread: Broncos -3.5 (-110)
• Total: 48.5 (Over -110/Under -110)

Sunday Night Football – Oct. 26

Green Bay Packers vs. Pittsburgh Steelers

• Spread: Packers -3 (-110)
• Total: 44.5 (Over -110/Under -110)

Monday Night Football – Oct. 27

Washington Commanders vs. Kansas City Chiefs

• Spread: Chiefs -9.5 (-118)
• Total: 48.5 (Over -110/Under -110)

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Odds refresh periodically and are subject to change.

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