ESPN FPI Predicts Outcome of Ole Miss Football's Remaining Schedule After Week 4 Win

Lane Kiffin and the Co. are preparing for a tremendous Week 5 challenge, ESPN's Football Power Index predicts season outcome.
Sep 20, 2025; Oxford, Mississippi, USA; Mississippi Rebels wide receiver Deuce Alexander (11) reacts after a catch during the third quarter against the Tulane Green Wave at Vaught-Hemingway Stadium. Mandatory Credit: Petre Thomas-Imagn Images
Sep 20, 2025; Oxford, Mississippi, USA; Mississippi Rebels wide receiver Deuce Alexander (11) reacts after a catch during the third quarter against the Tulane Green Wave at Vaught-Hemingway Stadium. Mandatory Credit: Petre Thomas-Imagn Images | Petre Thomas-Imagn Images

No. 13 Ole Miss returns to action in Week 5 for a Southeastern Conference showdown against the LSU Tigers with both programs entering the matchup unbeaten.

Lane Kiffin and Co. are coming off of back-to-back impressive performances with the offense being led by Division II All-American quarterback Trinidad Chambliss where he remains an effective weapon.

Ole Miss signal-caller Austin Simmons continues nursing an ankle injury suffered in Week 2 at Kentucky, and heading into "LSU Week," is yet to be at 100 percent.

“These guys are really good and they’re loaded on defense. They’re the best they’ve been on defense since we played them, obviously with the (offseason) acquisitions that we talked about," Kiffin said of LSU on Monday.

"Really (good) at shutting down the run. So, we’ll have to evaluate his health and then make a decision. (Monday) was just a walkthrough, so not enough to evaluate. But, at a 100 percent [Austin Simmons is] our starting quarterback.”

Ole Miss Rebels Football: Simmons.
Courtesy of Ole Miss Rebels Football.

LSU will be preparing for both quarterbacks during game preparation this week with both Chambliss and Simmons providing problems.

Brian Kelly took the podium on Monday where he detailed the thought process ahead of the matchup.

“In some instances it’ll be like playing Texas A&M last year. Those are two different quarterbacks,” Kelly said on Monday. “One was a pro-style quarterback and one was certainly a dual-threat that can run zone reads and do things of that nature. It changes you, dramatically.

“This week, both these quarterbacks are similar. Now they have different skillsets, but they can run the same offense with both of these players. I’m not saying it’s easier. It’s hard, right. You got two really good players but it’s not as one is a pro-style quarterback and is not going to run and the other is simply a dual-threat. They’re both very similar.”

Now, with the Ole Miss schedule set to ramp up, the ESPN Football Power Index has identified the program's most challenging game remaining.

Ole Miss Rebels Football: Trinidad Chambliss.
Courtesy of Ole Miss Rebels Football.

A look into the Week 5 game information and ESPN Football Power Index winning percentages for each game on the slate.

The Game Information: Week 5 Edition

Matchup: Ole Miss Rebels vs. LSU Tigers
Kickoff Time: 2:30 p.m. CT
Venue: Vaught Hemingway Stadium - Oxford (Miss.)
TV Channel: ABC
Radio: LSU Sports Radio Network
LSU Tigers Record: 4-0 (1-0 SEC)
Ole Miss Rebels Record: 4-0 (2-0 SEC)

Ole Miss Rebels Football.
Courtesy of Ole Miss Rebels Football.

The Ole Miss Matchup Predictor Chances:

*Note: The percentages reflect Ole Miss' chances to earn a win.*

LSU (September 27) – 73.3 percent chance to win
Washington St. (October 11) – 99.0 percent chance to win
at Georgia (October 18) – 40.2 percent chance to win
at Oklahoma (October 25) – 57.3 percent chance to win
vs. South Carolina (November 1) – 85.8 percent chance to win
vs. The Citadel (November 8) – 99 percent chance to win
vs. Florida (November 15) – 85.1 percent chance to win
at Mississippi St. (November 28) - 78.6 percent chance to win

The Ole Miss Rebels are favored in every matchup remaining except the program's SEC road matchup against Kirby Smart and the Georgia Bulldogs on Oct. 18.

Ole Miss Rebels Football.
Courtesy of Ole Miss Rebels Football.

No. 13 Ole Miss will return to action in Week 5 against the LSU Tigers at Vaught Hemingway Stadium with kickoff set for 2:30 p.m. CT.

More Ole Miss News:

The Ole Miss Football Depth Chart: Lane Kiffin and Co. Gearing Up for 2025 Season

Ole Miss Football 'Impressing' Texas Longhorns, Ohio State Buckeyes Target

Alabama Head Coach Betting Odds: Ole Miss Football's Lane Kiffin Listed as a Favorite

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Follow Zack Nagy on Twitter: @znagy20 and Ole Miss Rebels On SI: @OleMissOnSI for all coverage surrounding the Ole Miss program.

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Zack Nagy
ZACK NAGY

Zack Nagy is the Managing Editor and Publisher of Ole Miss Rebels On SI, a Sports Illustrated Publication. Nagy has covered Rebel Football, Baseball, Basketball and Recruiting, looking to keep readers updated on anything and everything involving Ole Miss athletics. Nagy has covered the Southeastern Conference for over half a decade after being born and raised in New Orleans (La.).

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