Wade Miley pitched eight strong innings to extend his mastery over the Rockies. He also had a career-best three hits, including an RBI single and benefited from a defense that turned five double plays as the Diamondbacks won for just the second time in nine games this season.
Miley improved to 7-0 with a 2.52 ERA in 10 career games (nine starts) against the Rockies, matching the longest winning streak against Colorado to start a career.
The winning pitcher in Arizona's only other victory this season, Miley (2-1) allowed two runs and seven hits.
Addison Reed gave up a leadoff single to Carlos Gonzalez in the ninth and Gonzalez stole second and went to third on catcher Miguel Montero's throwing error. Troy Tulowitzki walked to put runners on the corners.
Trumbo, who walked in his first two plate appearances, connected off Brett Anderson (0-2) for his fifth home run of the season, a two-run shot in the fifth that sailed into the left field bleachers and stretched Arizona's lead to 5-0. Anderson went six innings and allowed five runs and 10 hits.
Colorado got on the scoreboard with sacrifice flies by Drew Stubbs in the fifth and Arenado in the sixth.
A rare error by Arenado, last season's Gold Glove winner at third base, opened the door to a pair of unearned runs for the Diamondbacks in the third inning. Paul Goldschmidt's hard grounder kicked off his glove, allowing A.J. Pollock and Aaron Hill, who were aboard with singles, to score.
Chris Owings doubled and scored on Miley's fourth-inning single.
The new replay rule figured in a reversed call in the first inning. First base ump Mike Muchlinski called Colorado leadoff batter Charlie Blackmon out, but the replay showed Blackmon beat first baseman Goldschmidt's flip to Miley, covering the bag, getting his hand on the base with a headfirst slide just ahead of Miley stepping on the bag.
NOTES: The five double plays tied an Arizona club record. ... Brett Myers (April 23, 2003-April 11, 2009) and John Smoltz (May 6, 1993-Aug. 11, 1996) also had seven-game winning streaks against the Rockies to start their careers. ... Rockies 1B Justin Morneau had a designated day off on Sunday. ... The Diamondbacks have a day off before opening a three-game set at San Francisco on Tuesday. RHP Trevor Cahill (0-2) is set to go for the Diamondbacks against the Giants' RHP Tim Hudson (1-0). ... The Rockies open an interleague series Monday against the Chicago White Sox with RHP Jordan Lyles (1-0) facing Chicago's RHP Felipe Paulino (0-0). ... Total time for the replay review, initiated by Rockies manager Walt Weiss, was 2 minutes, 14 seconds. ... Trumbo has five home runs and 13 RBIs in six career games at Coors Field.