It will be made up Sunday as part of a separate-admission doubleheader. The originally scheduled game Sunday is set for 1:35 p.m. and the makeup is slated to begin at 7:05 p.m.
Rain soaked the Baltimore area for much of Saturday and was not expected to let up until well after midnight, forcing the postponement.
This is the Indians' lone scheduled visit to Camden Yards.
Knowing the weather forecast heading into the weekend, the Orioles scratched right-hander Kevin Gausman from his start at Triple-A Norfolk on Friday. He will likely be recalled to start one of the games on Sunday.
Baltimore won the opener of the three-game series Friday night, 4-3.