Best NFL Picks and Predictions Today for Week 6 (Picks for Patriots-Saints, Lions-Chiefs, and Seahawks-Jaguars)

We have a loaded slate of NFL games to watch and bet on today, so if you haven't already, it's time to place your bets.
If you're looking for some plays today, you've come to the right place. In this article, I'm going to break down my top three bets for Sunday's Week 7 slate. Let's dive into them.
NFL Best Bets Today for Week 7
- Patriots vs. Saints OVER 46 (-109) via Caesars
- Seahawks -104 vs. Jaguars via FanDuel
- Lions +120 vs. Chiefs via FanDuel
Patriots vs. Saints Prediction
I've been on the "Spencer Rattle isn't that bad" train for the past two weeks, and the Saints quarterback continues to climb up quarterback rankings, now ranking above the likes of Bo Nix, Justin Herbert, and Jayden Daniels in EPA+CPOE (expected points added + completion percentage over expected). With that being said, I don't have much faith in the Saints' defense, so I'm going to bet the OVER in their Week 6 game against the New England Patriots.
The Patriots are built to be the perfect OVER team. The Patriots rank 10th in EPA per play but 23rd in opponent EPA per play. When looking at the advanced metric called DVOA, these two defenses rank 27th and 29th. I'm surprised the total is set in the mid-40s, so give me the OVER.
Pick: OVER 46 (-109)
Seahawks vs. Jaguars Prediction
After hitting Bills +360 and Broncos +184 last week, @IainMacBets bet the Seahawks at -104 odds over the Jaguars @FDSportsbook this week. pic.twitter.com/BFPGa5Lgr5
— SI Betting (@SI_Betting) October 10, 2025
I'm very high on the Seattle Seahawks, despite their Week 5 loss to the Tampa Bay Buccaneers. The advanced metrics love this team, as they rank second in the league in DVOA, coming in at third in offensive DVOA, eighth in defensive DVOA, and first in special teams DVOA. Sam Darnold has also been fantastic to start the season, leading the league in adjusted EPA per play and Completion Percentage Over Expected.
The Jaguars' defense has been solid to start their season, but their offense has been less than stellar, and Trevor Lawrence's play has been masked by their winning record. I'm shocked the Seahawks are listed at a pick'em price. I think the Jaguars are completely outclassed in this game.
Pick: Seahawks -104
Lions vs. Chiefs
I was ready to bet against the Lions this week based on their recent competition, but DVOA, which adjusts for strength of opponent, has the Lions ranked as the No. 1-ranked team in the league. Not only do they rank in the top four on both offense and defense, but they're also fourth in special teams DVOA. Their defense has been far better than people give them credit for, ranking sixth in opponent EPA and third in opponent success rate.
The Chiefs' win against the Ravens doesn't look quite as good as it did a couple of weeks ago. I'm not quite sold on this team belonging in the elite tier in the NFL this season, so I'll back the Lions in this spot.
Pick: Lions +120
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You can check out all of Iain's bets here!
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