Davide Moretti scored a game-high 18 points to lead the Red Raiders over the top-ranked Cardinals at Madison Square Garden.
The younger brother of Timberwolves guard Jarrett Culver scored 100 points on 62 shots Tuesday night.
Another top-five program fell to an unranked opponent as Penn State knocked off Maryland at the Bryce Jordan Center.
The Bears earned their second straight win over a Top 25 team.
Jordan Nwora and Steven Enoch both notched double-doubles as the Cardinals proved to be worthy of the No. 1 ranking.