Virginia was originally slotted to play Florida on Friday, but the Gators pulled out of "Bubbleville" due to COVID-19 issues within their program.
The decision comes after Gonzaga's COVID-19 testing on Thursday.
Jeremiah Robinson-Earl scored a career-high 28 points to lead Villanova past Arizona State 83-74 in the championship game of the Empire Classic.
The top-ranked Gamecocks secured their second-largest margin of victory in program history.
Several college basketball games and events, including the Justin Reed Ole Miss Classic, have been canceled.