Bills vs. Panthers Final Score Prediction for NFL Week 8 (Buffalo Rallies to Cover)

Buffalo is sliding fast and could use a step in the right direction.

Josh Allen and the Buffalo Bills are favored against the Carolina Panthers on Sunday. / Dale Zanine-Imagn Images

The NFL’s reigning MVP is looking for redemption and will look to find it against one of the NFL’s hottest teams in Week 8. Josh Allen and the Buffalo Bills will visit the Carolina Panthers on Sunday as a 7.5-point road favorite after losing their second straight game in Week 7. The Panthers have won three straight and have all the momentum ahead of this matchup, though.

The Bills kicked off the year with four straight wins and appeared to be real contenders, but their point production has dropped off drastically since then. The Panthers have found comfort in their sturdy run defense, and staying strong in that area will be key against James Cook. Especially with Bryce Young listed as doubtful because of an ankle injury. Can Carolina prevent Buffalo from bouncing back?

Here’s our score prediction for the matchup ahead of kickoff.

Bills vs. Panthers Odds, Spread and Total

Odds via FanDuel Sportsbook

Spread

• Bills: +7.5 (-112)
• Panthers: -7.5 (-108)

Moneyline

• Bills: -390
• Panthers: +310

Total

• 46.5 (Over -105/Under -115)

Carolina has quietly been one of the NFL’s better teams against the spread this season. The Panthers have covered in five of their seven games while the Bills have only covered twice.

Bills vs. Panthers Final Score Prediction

Young has made strides to improve in 2025 but is dealing with a high ankle sprain that could keep him off the gridiron for a few weeks. Andy Dalton appears poised to step in as Carolina’s fill-in starter, and we’ve seen what the Panthers look like with him running the offense.

The Panthers were 1-4 straight up and against the spread in the four games Dalton started in last season. They averaged 19.4 points per game in those contests. Dalton has looked solid in the limited action he’s gotten this year, but history tells us that Carolina is worse off with him running the show.

Allen, Cook and the Bills receiving corps should have enough in the tank to win and cover the spread against Carolina without Young.

Final Score Prediction:  Bills 28, Panthers 20

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Odds refresh periodically and are subject to change.

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