Cardinals vs. Cowboys Prediction, Odds, Spread, Injuries, Trends for NFL Week 9

Iain MacMillan | Oct 29, 2025

The Cowboys are home favorites against the Cardinals in NFL Week 9 action. / Matt Kartozian-Imagn Images

The Dallas Cowboys can still make a push for the playoffs, but they can ill-afford to lose many more games, especially against the likes of the 2-5 Arizona Cardinals.

Thankfully for the Cowboys, they're set as home favorites over the Cardinals in this NFC duel in the Week 9 edition of Monday Night Football. Let's dive into the odds and my best bet for the Week 9 finale.

Cardinals vs. Cowboys Odds, Spread, and Total

Odds via Caesars Sportsbook

Spread

• Cardinals +2.5 (+107)
• Cowboys -2.5 (-127)

Moneyline

• Cardinals +125
• Cowboys -154

Total

• OVER 54 (-108)
• UNDER 54 (-112)

Cardinals vs. Cowboys How to Watch

• Date: Monday, Nov. 3
• Game Time: 8:15 pm ET
• Venue: AT&T Stadium
• How to Watch (TV): ABC/ESPN
• Cardinals Record: 2-5
• Cowboys Record: 3-4-1

Cardinals vs. Cowboys Betting Trends

• Cardinals are 12-6 ATS in their last 18 games
• The OVER is 8-4 in the Cardinals' last 12 games
• Cardinals are 7-1 straight up and ATS in their last eight games vs. Cowboys
• Cardinals are 11-1 ATS in their last 12 games vs. NFC East opponents
• The OVER is 5-0 in the Cowboys' last five games
• Cowboys are 1-5 ATS in their last six games vs. NFC West opponents

Cardinals vs. Cowboys Injury Reports

Cardinals Injury Report

• Garrett Williams, CB - IR-R
• Kyler Murray, QB - Questionable
• Emari Demercado, RB - Questionable
• Kitan Crawford, S - Questionable
• Walter Nolen III, DT - PUP-R

Cowboys Injury Report

• Perrion Winfrey, DT - IR-R
• Trevon Diggs, CB - IR
• Donovan Wilson, S - Questionable
• Juanyeh Thomas, S - Questionable
• Jack Sanborn, LB - Questionable

Cardinals vs. Cowboys Key Player to Watch

Despite the Cowboys' losing record, Dak Prescott has had a phenomenal season. He has completed 70.3% of passes for 2,068 yards, 16 touchdowns, and five interceptions. For the Cowboys to go on a run in the second half of the season, they need Prescott to keep playing at that level to help them overcome a weak defense.

Cardinals vs. Cowboys Prediction and Pick

In this week's edition of the Road to 272 Bets, I broke down why I'm laying the field goal with the Cowboys:

Kyler Murray is on track to be back for the Cardinals, but that may not be good news for Arizona fans and bettors. Jacoby Brissett ranks 13th in EPA+CPOE, while Murray comes in at 21st in that stat. Yes, he gets to face a bad Cowboys' offense, but I don't think he's played well enough for the Cardinals to only be 3-point underdogs.

The Cowboys are fifth in the league in EPA per play and fourth in offensive DVOA. They're going to score early and often in this game, and I don't think the Cardinals' offense will be able to match the rate they're scoring at.

Pick: Cowboys -2.5 (-127) via Caesars

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