Is De'Aaron Fox Playing Tonight? (Injury Update, Betting Impact for Spurs vs. Mavs)

In this story:
San Antonio Spurs guard De’Aaron Fox has been ruled out for the team’s season opener against the Dallas Mavericks with a hamstring injury.
Fox isn’t expected to miss a large chunk of time, but he has been dealing with the hamstring issue since training camp.
De'Aaron Fox (hamstring) ruled out for Wednesday.
— Underdog NBA (@UnderdogNBA) October 21, 2025
This is a pretty big blow to the Spurs’ offense, but they do have two young guards that are capable of helping fill in the gap for Fox. No. 2 overall pick Dylan Harper and reigning Rookie of the Year Stephon Castle should play bigger roles on Wednesday – and until Fox returns.
Fox and Victor Wembanyama only played a handful of games together last season due to injuries, and the Spurs are hoping that won’t be the case this season.
Here’s a look at how to bet on the Spurs in the prop market on Wednesday night.
Best Spurs Prop Bet vs. Mavericks on Opening Night
Odds via DraftKings Sportsbook.
Earlier today, I shared in my NBA Best Bets column – Peter’s Points – why Victor Wembanyama is a great prop target against Dallas:
Victor Wembanyama OVER 2.5 3-Pointers Made (+109)
The blood clots are gone, and Wemby is back and ready to stake his claim as an All-NBA player this season.
Last season, Wemby averaged 3.1 made 3-pointers on 8.8 attempts per game (shooting 35.2 percent), and I expect him to be right around that volume again in the 2025-26 season – especially with De’Aaron Fox banged up.
The former No. 1 overall pick went from taking 5.5 3-pointers per game as a rookie to 8.8 last season and his 3-point percentage improved from 32.5 percent to 35.2 percent. That’s a massive step forward for a young player attempting the 3-ball at such a high rate.
Dallas has a lot of options to defend Wemby, but I’m not sure any of them are truly going to stop him from launching 3-pointers. If anything, all the size Dallas has in its frontcourt rotation may make Wemby more prone to attacking from beyond the arc and avoiding all the shot-blockers at the rim.
This line is a steal at plus money for a player that attempts nearly nine shots from deep per night.
Odds refresh periodically and are subject to change.
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Find Peter Dewey's NBA betting record here (futures included). You can also follow my daily plays on BetStamp here.
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Peter is a senior editor for Sports Illustrated Betting. He has worked as a writer and editor for BetSided, NBC Sports, the Connecticut Sun and the Meriden Record-Journal covering the NBA, WNBA, NFL, MLB, and more. A New York City resident, he is a hoops fanatic with a soft spot for his New York Knicks.
Follow @peterdewey2