Is De'Aaron Fox Playing Tonight? (Injury Update, Betting Impact for Spurs vs. Mavs)

The latest injury update for San Antonio Spurs guard De'Aaron Fox on Wednesday night against the Dallas Mavericks.

San Antonio Spurs guard De'Aaron Fox. / Jesse Johnson-Imagn Images

San Antonio Spurs guard De’Aaron Fox has been ruled out for the team’s season opener against the Dallas Mavericks with a hamstring injury.

Fox isn’t expected to miss a large chunk of time, but he has been dealing with the hamstring issue since training camp.

De'Aaron Fox (hamstring) ruled out for Wednesday.

— Underdog NBA (@UnderdogNBA) October 21, 2025

This is a pretty big blow to the Spurs’ offense, but they do have two young guards that are capable of helping fill in the gap for Fox. No. 2 overall pick Dylan Harper and reigning Rookie of the Year Stephon Castle should play bigger roles on Wednesday – and until Fox returns.

Fox and Victor Wembanyama only played a handful of games together last season due to injuries, and the Spurs are hoping that won’t be the case this season.

Here’s a look at how to bet on the Spurs in the prop market on Wednesday night. 

Best Spurs Prop Bet vs. Mavericks on Opening Night

Odds via DraftKings Sportsbook.

Earlier today, I shared in my NBA Best Bets column – Peter’s Points – why Victor Wembanyama is a great prop target against Dallas: 

Victor Wembanyama OVER 2.5 3-Pointers Made (+109)

The blood clots are gone, and Wemby is back and ready to stake his claim as an All-NBA player this season. 

Last season, Wemby averaged 3.1 made 3-pointers on 8.8 attempts per game (shooting 35.2 percent), and I expect him to be right around that volume again in the 2025-26 season – especially with De’Aaron Fox banged up. 

The former No. 1 overall pick went from taking 5.5 3-pointers per game as a rookie to 8.8 last season and his 3-point percentage improved from 32.5 percent to 35.2 percent. That’s a massive step forward for a young player attempting the 3-ball at such a high rate.

Dallas has a lot of options to defend Wemby, but I’m not sure any of them are truly going to stop him from launching 3-pointers. If anything, all the size Dallas has in its frontcourt rotation may make Wemby more prone to attacking from beyond the arc and avoiding all the shot-blockers at the rim. 

This line is a steal at plus money for a player that attempts nearly nine shots from deep per night.

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Odds refresh periodically and are subject to change.

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Find Peter Dewey's NBA betting record here (futures included). You can also follow my daily plays on  BetStamp here.

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