NFL Straight-Up Moneyline Picks for Every Game in Week 13

SI Staff | Nov 26, 2025

The Sports Illustrated team gives their picks for all 16 games in Week 13 of the 2024 NFL season. / Sports Illustrated

We have a new member of the profitable club! After Peter Dewey posted a strong 12-2 record for +3.93 units in Week 12, he got his season-to-date record back to the positive. He joins Clare Brennan, Matt Verderame, and Conor Orr as the group of panelists sitting with a profit after picking the winner of every game through the first 12 weeks.

It's time to move on to Week 13, which includes Thanksgiving Day and Black Friday! Let's take a look at everyone's picks for this week's slate of games.

Week 12 Results

• Clare Brennan, Associate Editor 10-4 (-0.06 units)
• Mitch Goldich, Senior Editor 11-3 (+1.48 units)
• Gilberto Manzano, NFL Staff Writer 10-4 (+1.10 units)
• Conor Orr, Senior Writer 10-4 (+0.8 units)
• John Pluym, NFL Managing Editor 10-4 (+1.39 units)
• Matt Verderame, NFL Staff Writer 11-3 (+1.48 units)
• Iain MacMillan, Senior Editor, Betting 10-4 (+1.41 units)
• Peter Dewey, Associate Managing Editor, Betting 12-2 (+3.93 units)

Season-to-Date Results

• Clare Brennan, Associate Editor 117-60-1 (+0.57 units)
• Mitch Goldich, Senior Editor 116-61-1 (-2.06 units)
• Gilberto Manzano, NFL Staff Writer 105-82-1 (-15.21 units)
• Conor Orr, Senior Writer 120-57-1 (+16.22 units)
• John Pluym, NFL Managing Editor 112-65-1 (-5.96 units)
• Matt Verderame, NFL Staff Writer 123-54-1 (+8.74 units)
• Iain MacMillan, Senior Editor, Betting 104-73-1 (-13.67 units)
• Peter Dewey, Associate Managing Editor, Betting 117-61-1 (+0.64 units)

NFL Week 13 Picks

NFL Week 13 Picks / Sports Illustrated

All odds are via DraftKings Sportsbook

Packers (+120) vs. Lions (-142)

• Clare Brennan: Lions
• Mitch Goldich: Lions
• Gilberto Manzano: Packers
• Conor Orr: Lions
• John Pluym: Lions
• Matt Verderame: Lions
• Iain MacMillan: Packers
• Peter Dewey: Lions

Chiefs (-185) vs. Cowboys (+154)

• Clare Brennan: Chiefs
• Mitch Goldich: Chiefs
• Gilberto Manzano: Chiefs
• Conor Orr: Chiefs
• John Pluym: Chiefs
• Matt Verderame: Chiefs
• Iain MacMillan: Chiefs
• Peter Dewey: Chiefs

Bengals (+280) vs. Ravens (-355)

• Clare Brennan: Ravens
• Mitch Goldich: Ravens
• Gilberto Manzano: Ravens
• Conor Orr: Ravens
• John Pluym: Ravens
• Matt Verderame: Ravens
• Iain MacMillan: Bengals
• Peter Dewey: Ravens

Bears (+270) vs. Eagles (-340)

• Clare Brennan: Eagles
• Mitch Goldich: Eagles
• Gilberto Manzano: Eagles
• Conor Orr: Bears
• John Pluym: Eagles
• Matt Verderame: Eagles
• Iain MacMillan: Eagles
• Peter Dewey: Eagles

49ers (-245) vs. Browns (+200)

• Clare Brennan: 49ers
• Mitch Goldich: 49ers
• Gilberto Manzano: 49ers
• Conor Orr: Browns
• John Pluym: 49ers
• Matt Verderame: 49ers
• Iain MacMillan: Browns
• Peter Dewey: 49ers

Jaguars (-285) vs. Titans (+230)

• Clare Brennan: Jaguars
• Mitch Goldich: Jaguars
• Gilberto Manzano: Jaguars
• Conor Orr: Jaguars
• John Pluym: Jaguars
• Matt Verderame: Jaguars
• Iain MacMillan: Titans
• Peter Dewey: Jaguars

Texans (+180) vs. Colts (-218)

• Clare Brennan: Colts
• Mitch Goldich: Texans
• Gilberto Manzano: Texans
• Conor Orr: Colts
• John Pluym: Colts
• Matt Verderame: Texans
• Iain MacMillan: Texans
• Peter Dewey: Texans

Saints (+215) vs. Dolphins (-265)

• Clare Brennan: Dolphins
• Mitch Goldich: Dolphins
• Gilberto Manzano: Dolphins
• Conor Orr: Dolphins
• John Pluym: Dolphins
• Matt Verderame: Dolphins
• Iain MacMillan: Saints
• Peter Dewey: Dolphins

Falcons (-148) vs. Jets (+124)

• Clare Brennan: Falcons
• Mitch Goldich: Falcons
• Gilberto Manzano: Falcons
• Conor Orr: Falcons
• John Pluym: Falcons
• Matt Verderame: Jets
• Iain MacMillan: Falcons
• Peter Dewey: Falcons

Cardinals (+120) vs. Buccaneers (-142)

• Clare Brennan: Buccaneers
• Mitch Goldich: Cardinals
• Gilberto Manzano: Cardinals
• Conor Orr: Buccaneers
• John Pluym: Buccaneers
• Matt Verderame: Buccaneers
• Iain MacMillan: Cardinals
• Peter Dewey: Cardinals

Rams (-700) vs. Panthers (+500)

• Clare Brennan: Rams
• Mitch Goldich: Rams
• Gilberto Manzano: Rams
• Conor Orr: Rams
• John Pluym: Rams
• Matt Verderame: Rams
• Iain MacMillan: Rams
• Peter Dewey: Rams

Vikings (+5000 vs. Seahawks (-700)

• Clare Brennan: Seahawks
• Mitch Goldich: Seahawks
• Gilberto Manzano: Seahawks
• Conor Orr: Seahawks
• John Pluym: Seahawks
• Matt Verderame: Seahawks
• Iain MacMillan: Seahawks
• Peter Dewey: Seahawks

Bills (-185) vs. Steelers (+154)

• Clare Brennan: Bills
• Mitch Goldich: Bills
• Gilberto Manzano: Bills
• Conor Orr: Bills
• John Pluym: Bills
• Matt Verderame: Bills
• Iain MacMillan: Bills
• Peter Dewey: Bills

Raiders (+425) vs. Chargers (-575)

• Clare Brennan: Chargers
• Mitch Goldich: Chargers
• Gilberto Manzano: Chargers
• Conor Orr: Chargers
• John Pluym: Chargers
• Matt Verderame: Chargers
• Iain MacMillan: Chargers
• Peter Dewey: Chargers

Broncos (-290) vs. Commanders (+235)

• Clare Brennan: Broncos
• Mitch Goldich: Broncos
• Gilberto Manzano: Broncos
• Conor Orr: Broncos
• John Pluym: Broncos
• Matt Verderame: Broncos
• Iain MacMillan: Broncos
• Peter Dewey: Broncos

Giants (+320) vs. Patriots (-410)

• Clare Brennan: Patriots
• Mitch Goldich: Patriots
• Gilberto Manzano: Patriots
• Conor Orr: Patriots
• John Pluym: Patriots
• Matt Verderame: Patriots
• Iain MacMillan: Patriots
• Peter Dewey: Patriots

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