Orioles vs. Yankees Prediction, Odds, Probable Pitchers and Prop Bets for Saturday, June 21

The Baltimore Orioles took their series opener against the New York Yankees on Friday night, but they find themselves as road underdogs on Saturday afternoon.

The Yankees are in trouble right now, losing seven of their last eight games to shrink their lead atop the AL East to just 1.5 games.

Luckily for New York, starter Clarke Schmidt is on the mound on Saturday, and he’s been lights out as of late, holding opponents scoreless in each of his last two outings. He’ll take on Baltimore starter Zach Eflin (4.81 ERA), who is coming off his worst start of the season, allowing 12 hits and seven runs in a loss to the Tampa Bay Rays.

Here’s a breakdown of the odds, players to bet in the prop market and my prediction for Saturday’s AL East showdown.

Orioles vs. Yankees Odds, Run Line and Total

Odds via DraftKings Sportsbook.

Run Line

Orioles +1.5 (-144)
Yankees -1.5 (+118)

Moneyline

Orioles: +143
Yankees: -175

Total

9.5 (Over -102/Under -119)

Orioles vs. Yankees Probable Pitchers

Baltimore: Zach Eflin (6-3, 4.81 ERA)
New York: Clarke Schmidt (3-3, 3.16 ERA)

Orioles vs. Yankees How to Watch

Date: Saturday, June 21
Time: 1:05 p.m. EST
Venue: Yankee Stadium
How to Watch (TV): YES, MASN
Orioles record: 32-42
Yankees record: 43-32

Orioles vs. Yankees Best MLB Prop Bets

Yankees Best MLB Prop Bet

Clarke Schmidt UNDER 4.5 Hits Allowed (+110)

This season, Schmidt ranks in the 89th percentile in expected batting average against (.207), and he’s allowed just 48 hits in 62.2 innings of work.

I love this plus money prop for him against a Baltimore team that is 22nd in MLB in batting average and 23rd in hits in the 2025 season.

Schmidt has allowed four or fewer hits in seven of his 11 starts in 2025, and he’s given up just six hits (and no runs) over his last two outings (13.2 innings of work).

Orioles vs. Yankees Prediction and Pick

Earlier on Saturday, I shared in SI Betting’s best MLB bets column – Walk-Off Wagers – why I’m taking the Yankees to win on Saturday afternoon:

The New York Yankees lost again on Friday night – even with ace Max Fried on the mound – but I am buying them as a bounce-back candidate on Saturday.

Righty Clarke Schmidt is on the mound for New York and he’s been lights out as of late, posting a 2.38 ERA over his last nine starts. Schmidt ranks in the 91st percentile in expected ERA (2.77) and the 89th percentile in expected batting average against (.207) so far in 2025.

Meanwhile, Orioles righty Zach Eflin has struggled as of late, allowing seven runs and 12 hits in his last outing to push his ERA to 4.81 in the 2025 season.

Baltimore is 6-4 in his starts, but Eflin has allowed five or more runs in three of his last six outings.

This New York offense – despite some recent struggles – is still one of the five best in several key statistics this season, including runs scored, OPS and Weighted Runs Created Plus (wRC+).

With Schmidt dealing as of late, the Yankees are a prime bounce-back candidate on Saturday afternoon.

Pick: Yankees Moneyline (-175 at DraftKings)

Odds refresh periodically and are subject to change.

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