Patrick Mahomes Injury Has Massive Impact on Chiefs vs. Titans Odds for Week 16

Kansas City Chiefs quarterback Patrick Mahomes suffered a torn ACL on Sunday, and it's impacted the team's odds for Week 16 and beyond.

Kansas City Chiefs quarterback Patrick Mahomes. / Jay Biggerstaff-Imagn Images

The Kansas City Chiefs' 2025 season when from bad to disastrous in just one play on Sunday.

Superstar quarterback Patrick Mahomes suffered a torn ACL against the Los Angeles Chargers, and the Chiefs went on to lose the game, eliminating them from playoff contention for the first time in 11 seasons.

Chiefs QB Patrick Mahomes did in fact tear his ACL. pic.twitter.com/3YSufi4aez

— Adam Schefter (@AdamSchefter) December 15, 2025

Mahomes' injury has had a dramatic impact on the team's odds for Week 16 and beyond, even though most of the Chiefs' futures are done. At DraftKings, the Chiefs are still favored on the road in Week 16 against the two-win Tennessee Titans, but the total for that game has shifted all the way down to just 37.5

As of Sunday night, the Chiefs' win total has been taken off the board with Kansas City sitting at 6-8 in the 2025 season. Mahomes and company were projected to win double-digit games entering the season, but Kansas City was a fringe playoff team even with the star quarterback healthy.

Mahomes shared a message on social media following the injury, and he certainly seems motivated to get back to the MVP level that he has showcased for basically all of his NFL career.

Don’t know why this had to happen. And not going to lie it’s hurts. But all we can do now is Trust in God and attack every single day over and over again. Thank you Chiefs kingdom for always supporting me and for everyone who has reached out and sent prayers. I Will be back…

— Patrick Mahomes II (@PatrickMahomes) December 14, 2025

With Kansas City eliminated from playoff contention, there are just 10 teams competing for the AFC playoff spots. The Denver Broncos have already clinched a spot, so the Indianapolis Colts, Baltimore Ravens and Miami Dolphins (who play on Monday night) only have a few spots up for grabs that they can grab.

The Chiefs finish the season against Tennessee, Denver and the Las Vegas Raiders. It's possible KC will be favored against Las Vegas as well, but there's no doubt that the team's ceiling is much, much different with Mahomes out of the lineup.

It'll be interesting to see if the Chiefs' line moves at all throughout the week.

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Odds refresh periodically and are subject to change.

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