USC vs. Nebraska Prediction, Odds and Key Players to Watch for College Football Week 10

Iain MacMillan | Oct 31, 2025

Nebraska is a six-point underdog at home against USC in college football Week 10 action. / Dylan Widger-Imagn Images

Nebraska has put together a solid 6-2 record through its first eight games this college football season, but there's still plenty of room for the Cornhuskers to improve on that, and they have a chance to capture a significant win against a ranked team when they face No. 23 USC in Week 10.

USC has lost two of its past three games, with losses to Illinois and Notre Dame. Can the Trojans now bounce back with a win as road favorites? Let's dive into it.

USC vs. Nebraska Odds, Spread, and Total

Odds via Caesars Sportsbook

Spread

• USC -6 (-110)
• Nebraska +6 (-110)

Moneyline

• USC -235
• Nebraska +192

Total

• OVER 59 (-110)
• UNDER 59 (-110)

USC vs. Nebraska How to Watch

• Date: Saturday, Nov. 1
• Game Time: 7:30 pm ET
• Venue: Memorial Stadium
• How to Watch (TV): NBC
• USC Record: 5-2
• Nebraska Record: 6-2

USC vs. Nebraska Betting Trends

• The OVER is 6-3 in USC's last nine games
• USC is 0-6 ATS in its last six games played in Week 10
• Nebraska is 0-4-1 ATS in its last five games
• The OVER is 6-1 in Nebraska's last seven games

USC vs. Nebraska Key Player to Watch

• Emmett Johnson, RB - Nebraska Cornhuskers

Emmett Johnson has been extremely impressive this season. The Nebraska running back has averaged 5.7 yards per carry this season, along with nine touchdowns. If he can get going against the USC defense, he has a chance to lead Nebraska to an upset victory.

USC vs. Nebraska Prediction and Pick

In this week's edition of First to Forde, I broke down Nebraska to cover as one of my best picks against the spread for Week 10:

USC has struggled when playing on the road this season. The Trojans have a point differential of +32.8 at home but just +1.3 on the road. The Trojans' defense has also struggled this season, ranking 108th in opponent adjusted EPA. Meanwhile, the Nebraska defense comes in at 54th in that stat. Don't overlook the Cornhuskers this week.

Pick: Nebraska +6 (-110) via Caesars

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