Yankees vs. Cardinals Prediction, Odds, Probable Pitchers and Prop Bets for Friday, Aug. 15

Iain MacMillan | Aug 15, 2025

The Yankees are road favorites against the Cardinals on Friday night. / Vincent Carchietta-Imagn Images

The New York Yankees have tumbled down the standings over the past two months, but all hope isn't lost. They need to find some momentum in a hurry heading into this weekend's series against the St. Louis Cardinals. They currently have just a 0.5 game lead on the final wild card spot and are 6.5 games behind the Toronto Blue Jays for the top spot in the AL East.

Let's take a look at the odds and my best bets for tonight's interleague series opener.

Yankees vs. Cardinals Odds, Run Line, and Total

Odds via Caesars Sportsbook

Run Line

• Yankees -1.5 (+118)
• Cardinals +1.5 (-140)

Moneyline

• Yankees -135
• Cardinals +115

Total

• Over 9 (+110)
• Under 9 (-130)

Yankees vs. Cardinals Probable Pitchers

• New York: Luis Gil, RHP (0-1, 7.27 ERA)
• St. Louis: Andre Pallante, RHP (6-9, 4.95 ERA)

Yankees vs. Cardinals How to Watch

• Date: Friday, August 15
• Time: 8:15 p.m. ET
• Venue: Busch Stadium
• How to Watch (TV): YES, FanDuel Sports Network Midwest
• Yankees Record: 64-57
• Cardinals Record: 61-61

Yankees vs. Cardinals Best MLB Prop Bet

• Andre Pallante OVER 2.5 Walks Allowed (+150) via Caesars

The Yankees have the highest walk rate in Major League Baseball this season. They have drawn a walk on 9.9% of their plate appearances in 2025. Tonight, they'll face Andre Pallante, who has a relatively high walk rate this season, giving up 3.0 walks per nine innings pitched. He had a start against the Padres earlier this month, where he allowed three walks in just 5.0 innings pitched. This is a great plus-money prop to bet on for tonight's slate.

Yankees vs. Cardinals Prediction and Pick

In today's edition of Walk-Off Wagers, I broke down why I'm backing the Yankees to get the win tonight:

The St. Louis Cardinals have been atrocious offensively of late. Since the All-Star Break, the Cardinals rank dead last in the Majors in OPS at .661. Tonight, they host the New York Yankees, who, while they haven't had a great record over the past month, still rank 18th in the Majors in OPS at .707. I'll back the Bronx Bombers as favorites tonight.

Pick: Yankees -135

---

Use our exclusive Caesars Sportsbook promo code SICZRDYW to double your winnings on your next 10 bets. Simply deposit $10 or more and place a first-time wager of at least $1, and Caesars will give you 10 100% profit boost tokens.

Odds refresh periodically and are subject to change.

If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.

You can check out all of Iain's bets here!