Illinois will face Purdue on Saturday without starting quarterback Brandon Peters, who has tested positive for COVID-19.
The Illini announced on Saturday morning that Peters and redshirt freshman tight end Griffin Moore returned positive tests. The school said "several other players" will also be sidelined this weekend and next week against Minnesota due to contract tracing.
Moore and Peters will miss 21 days due to Big Ten protocols and be eligible to return on Nov. 21 against Nebraska.
Peters went 8-for-19 for 87 yards with zero touchdowns in Illinois's season-opening loss to Wisconsin.
Sophomore Matt Robinson started at quarterback for the Illini but he was quickly replaced by fourth-stringer Coran Taylor.
An Illinois spokesperson added that the players who are held out for contact tracing quarantine are based on protocols from the Centers for Disease Control and the local health department protocol and not a Big Ten requirement.
The news of Illinois's two positive cases comes shortly after Wisconsin athletic director Barry Alvarez announced the Badgers' COVID-19 outbreak has grown to 22 cases. Wisconsin canceled this weekend's game against Nebraska due to the outbreak.