Colorado Buffaloes Substantial Betting Odds Released vs. TCU

The Colorado Buffaloes fell to a 2-3 record following a loss to the No. 25 BYU Cougars on Saturday. The Buffaloes will look to turn the page in week 6 against the No. 24 TCU Horned Frogs. Betting odds for the Buffaloes as they look to avoid another Big 12 loss.

Sep 20, 2025; Boulder, Colorado, USA; Colorado Buffaloes quarterback Kaidon Salter (3) before the game against the Wyoming Cowboys at Folsom Field. | Ron Chenoy-Imagn Images

The Colorado Buffaloes fell to a 2-3 record following a loss against the No. 25 BYU Cougars on Saturday night. Next up for Colorado coach Deion Sanders and the Buffaloes will be the TCU Horned Frogs.

Betting Odds

The Colorado Buffaloes are 13.5-point underdogs against TCU on FanDuel Sportsbook. The moneyline for Colorado is +420, and the point total is set at 53.5.

Colorado Keeps It Close vs. Byu

Sep 6, 2025; Boulder, Colorado, USA; Colorado Buffaloes head coach Deion Sanders before the game against the Delaware Fightin Blue Hens at Folsom Field. Mandatory Credit: Ron Chenoy-Imagn Images | Ron Chenoy-Imagn Images

The Colorado Buffaloes came out firing against BYU, scoring 14 points in the first quarter, limiting the Cougars to just three points. The Buffaloes led the game at halftime, and despite losing the lead in the third quarter, Colorado took it right back

The offense moved down the field well compared to the first couple of weeks of the season, mixing in the run game. Colorado quarterback Kaidon Salter is now up to 684 passing yards, five touchdowns, and one interception. He has also rushed for 202 yards and four touchdowns.

Wide receiver Joseph Williams is coming off a big game, now leading the team with 220 receiving yards and two touchdowns. The Buffaloes have seen several players step up in the receiving game, with three players with over 200 yards.

Oct 19, 2024; Tucson, Arizona, USA; Colorado Buffalos running back Micah Welch (29) against the Arizona Wildcats at Arizona Stadium. Mandatory Credit: Mark J. Rebilas-Imagn Images | Mark J. Rebilas-Imagn Images

Running back Micah Welch leads the team with 210 rushing yards and one touchdown. Colorado’s run game has improved greatly this season, and the Buffaloes will have to keep it up to win more games this season.

The Buffaloes' defense did well containing BYU's offense, as the Cougars did not score a touchdown until late in the second quarter. The weakness remains penalties and allowing the quarterback to run.

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Colorado safety Tawfiq Byard has been one of the top players for Colorado this season on the defense, totalling 35 total tackles and 0.5 sacks. 

Apr 4, 2025; Boulder, CO, USA; Colorado Buffaloes head coach Deion Sanders speaks to the media at the University of Colorado NFL Showcase at the CU Indoor Practice Facility. Mandatory Credit: Michael Ciaglo-Imagn Images | Michael Ciaglo-Imagn Images

One weakness for the team as a whole has been clock management. Colorado had possession of the ball in the final minutes of the game, only needing a field goal to tie it. Colorado had two timeouts and did not use either before Salter threw an interception that sealed the game for BYU. 

This is the second time this season that Sanders’ clock management has been called into question. The Buffaloes previously had the chance for a game-winning drive in week one against the No. 16 Georgia Tech Yellow Jackets.

TCU To Shake Off Loss?

Sep 26, 2025; Tempe, Arizona, USA; TCU Horned Frogs head coach Sonny Dykes looks on against Arizona State Sun Devils in the first half at Mountain America Stadium, Home of the ASU Sun Devils. Mandatory Credit: Jacob Reiner-Imagn Images | Jacob Reiner-Imagn Images

The No. 24 TCU Horned Frogs will be coming off their first loss of the season after facing an upset against the Arizona State Sun Devils.

TCU is led by quarterback Josh Hoover, who has passed for 1,242 yards, 11 touchdowns, and four interceptions. He is averaging 9.2 yards per pass and has spread the ball around well. Wide receiver Eric McAlister has just 13 receptions, but for 320 yards. Colorado will have to be ready to defend TCU’s strong passing game.

TCU has three players with over 100 rushing yards, with running back Kevorian Barnes leading the team with 156 yards. The good news for the Buffaloes is that Hoover totals -8 rushing yards, but Colorado will still have to prepare for the quarterback to take it himself.

The Colorado Buffaloes and No. 24 TCU Horned Frogs will kick off on Saturday, Oct. 4, at 5:30 p.m. MT at Amon G. Carter Stadium in Fort Worth, Texas.

• Game odds refresh periodically and are subject to change. 
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