Leonard Fournette and Shaq Lawson were both ejected.
Jaguars receiver Donte Moncrief caught a jump-ball over Bills cornerback Levi Wallace on Sunday, putting Jacksonville in position to break a 14–14 tie late in the third quarter at New Era Field in Buffalo. The two players fought for the ball near the left pylon following the catch, and tempers quickly flared between the two teams.
As Moncrief and Wallace laid on the ground, the two teams spilled toward the sideline edge, brawling near the fans in the left corner near the end zone.
Jacksonville running back Leonard Fournette ran off the sidelines and into the fight with his helmet on. He and Buffalo linebacker Shaq Lawson traded punches, leading to ejections for both players.
The Bills went on to win the game 24-21 to improve to 4-7 on the season. The Jaguars fell to 3-8 with their seventh straight loss.