Maradona was 60 years old.
Maradona underwent surgery to remove a blood clot on his brain on Nov. 4. He was released from the hospital eight days later and began to rehab in his home.
Maradona is one of the most decorated stars in soccer history. He tallied 259 career goals in nearly two decades of club competition, winning nine club titles. Maradona also recorded 34 goals in 91 caps for the Argentina national team, appearing in the World Cup four times.
Maradona is perhaps best known for his performance in the 1986 World Cup, when he helped Argentina defeat West Germany in the final. He scored twice in the quarterfinal against England: the "Hand of God" goal, which remains one of the most controversial in World Cup history, and the "Goal of the Century."
Maradona struggled with drug use both during and after his playing career. He was hospitalized in 2000 and 2004 for heart problems connected to cocaine use, and he was hospitalized once again in 2007 for acute hepatitis Doctors blamed the hospitalization on excessive drinking and eating. Maradona remains one of the greatest figures in soccer history, though he was not without his own share of personal demons.
The Argentinian legend turned to managing in recent decades. Maradona was the national coach for Argentina from 2008-10, most recently leading Argentinian clubs Dorados de Sinaloa and Gimnasia de La Plata.
Maradona is recognized as perhaps the greatest player of the 20th century. He and Brazilian legend Pele were named joint winners of the FIFA Player of the Century award in December 2000.
"Certainly one day we'll kick a ball together in the sky above," Pele said on Wednesday, per Sky Sports.
Maradona leaves behind one of the most celebrated resumes in soccer history. Only three players have logged more World Cup caps, and his nine World Cup goals ranks No. 9 all-time.