Kyler Murray and the Cardinals aim to compete in the NFC West, which looks to be one of the toughest divisions in the NFL. A season-opening win against the out-of-conference Titans could give Arizona early separation from its competition.
Tennessee will compete with the Kansas City Chiefs and Buffalo Bills for the top spot in the AFC.
How to Watch:
Date: Sept. 12, 2021
Time: 1 p.m. ET
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LIVE BLOG (all times ET): Updates, highlights and commentary
4:19pm - FINAL: 38-13 Cardinals
Kyler Murray (309 total yards and 5 touchdowns) and Chandler Jones (5 sacks) making the case for offensive and defensive players of the week out of the gates!
Derrick Henry (77 total yards on 20 touches) will be stewing on this one all week. One of his worst games in a few years
4:13pm - TWO MINUTE WARNING: Cardinals milked over 6 minutes off the clock before having to punt, penalty (of course) as the Titans take over with 1:55 to go and the game over.
4:04pm - Ryan Fitzpatrick is on literally every list in the history of football. What a weird career.
4:01pm - CARDINALS WITH ANOTHER SACK, CHA.... Sorry force of habit, this one was Michael Dogbe. Sixth sack of the day for the Cardinals, first not by Chandler Jones.
4:00pm - The score might be out of reach, but this is an opportunity to get some rhythm, momentum, especially between Tannehill and Jones in their first season together. A lot to gain in these final 10 minutes.
3:55pm - Tennessee gets the stop on 3rd down, missed 43 yard field goal by Matt Prater. Is there enough time to do anything of significance today? Cardinals 38-13
3:46pm - Not One. Not Two. Not Three. Not Four. But FIVE sacks from Chandler Jones, TURNOVER on downs. Cardinals up 38-13
3:41pm - Tannehill to Julio Jones for 11 yards and a first down. Great blocking there to keep Tannehill upright long enough to get the ball off. Titans to the hurry-up offense.
3:40pm - Chandler Jones two strip sacks lead to 14 Cardinal points.
Jones 14 - Titans 13
3:36pm - TOUCHDOWN! Kyler Murray to Christian Kirk (again) for 11 yards and the score. Kirk with two touchdowns. Hopkins with two touchdowns. Murray accounting for FIVE touchdowns today. 38-13 Cardinals.
3:33pm - TURNOVER! Chandler Jones with his FOURTH sack and SECOND forced fumble setting the Cardinals up just outside of the Red Zone.
3:30pm - DERRICK HENRY SIGHTING!!! Off the right side for 19 yards, followed up with a 4 yard run and an 8 yard run. Getting some momentum, but runs are not going to get them back in this with the clock ticking and ticking.
3:25pm - Tennessee makes up for that turnover sacking Murray on 3rd down and now they have a chance to chip into this lead. 8:25 to go in the 3rd Q
3:33pm - TURNOVER! Tipped ball turns into free jump for Isaiah Simmons to make the catch despite his teammate also trying to get their first turnover of the season.
3:22pm - The Cardinals Defense is just swallowing Derrick Henry today, 10 carries and 9 yards
3:17pm - TOUCHDOWN!!! Kyler Murray to Christian Kirk, just rears back and lofts up a ball to the WIDE OPEN Kirk for 22 yards. Too easy. Cardinals 31-13 with 10:40 to go in the 3rd Q
3:10pm - BOOM! One play. Inside Tennessee territory, Murray quick screen pass to Rondale Moore for 29 yards.
3:05pm - TOUCHDOWN! Tannehill with the DART to A.J. Brown for the score. Extra point finds its mark this time, 24-13 Cardinals
3:04pm - TURNOVER! Kyler Murray leaves it short and Kevin Byard gets his first interception of the season. Titans ready to go!
3:00pm - Injury on the field, Kelvin Beachum of the Cardinals (UPDATE: Beachum walked off on his own and went to the locker room)
2:59pm - Second half kicks off, Cardinals run it to the 26 yard line (Penalty flag: holding on Cardinals)
HALFTIME! Cardinals dominating both sides of the ball, up 24-6
Kyler Murray 15-22 201 yards two touchdowns and 19 yards rushing with another touchdown
DeAndre Hopkins 5 catches (6 targets) 73 yards and two touchdowns
Chandler Jones THREE SACKS
Derrick Henry contained, 9 carries and 8 yards (1 catch for 3 yards)
2:40pm - Missed FG by Michael Badgley from 46 yards on fourth and 1, the crowd let them hear it for not going for it with one timeout and down 18 points. 24-6 Cardinals.
2:35pm - Julio Jones with his first catch as a Tennessee Titan (9 yards) followed by a Tannehill keeper for 16 yards. Putting together a two minute drill!
2:30pm - TOUCHDOWN! Kyler Murray keeper, runs it in untouched. 24-6 Cardinals with 1:44 to go for the Titans to make something happen.
2:26pm - TWO MINUTE WARNING: Cardinals ball, 2nd and 10 on the 19 yard line
2:25pm - Murray to Christian Kirk in the TIGHTEST of windows for 20 yards, back in the Red Zone!
2:21pm - UNREAL athleticism from Kyler Murray scrambling and dodging sacks all day before pretty touch on a first down pass to Rondale Moore for 18 yards on 3rd and 10
1:15pm - TOUCHDOWN TENNESSEE! Ryan Tannehill play action keeper for the 1 yard run. Point after is missed. 17-6 Cardinals
1:14pm - Nick Westbrook-Ikhine sets up first and goal inside the 1 yard line! Back-to-back stuffs of Derrick Henry runs.
2:12pm - Wow, back-to-back pretty passes by Ryan Tannehill, hitting his guys in the hands and dropped.
2:10pm - BUST OUT THE FLEA FLICKER!!! The Titans are full of tricks today, 39 yards for Chester Rogers!
2:09pm - A.J Brown with his first catch of the day. Move the sticks!
2:03pm - TOUCHDOWN CARDINALS!!! SLICK MOVE BY DEANDRE HOPKINS!!! Catch. Spin. Run. Murray to Hopkins for 17 yards and his second score of the day! 17-0 Cardinals.
2:01pm - Another penalty by the Cardinals (holding, A.J. Green) negates a great 10+ yard designed run by Kyler Murray. Total Penalties: 5 for 39 yards
1:59pm - Cardinals matriculating the ball down the field, inside the 30 yard line of the Titans and multiple positive plays in a row.
1:55pm - End of Q1 10-0 Arizona
Chandler Jones 3 Sacks, 1 forced fumble leading the way as the Cardinals Defense is playing with fire. Five tackles for loss, 21 yards allowed through the air and 6 yards on the ground
Derrick Henry with 6 yards on 6 carries (long of 7 yards)
1:52pm - Cardinals with ANOTHER SACK and yes, it was Chandler Jones for his third sack of the first quarter. Man. On. A. Mission!
1:50pm - FAKE PUNT! Titans with the trickery and connect for the fourth down conversion and they have some momentum.
1:49pm - CHANDLER JONES WITH HIS SECOND SACK!!!
1:44pm - Tennessee with a HUGE stop after A.J. Green runs into Christian Kirk, incomplete pass. Punt carries into the end zone. Tennessee ball.
1:38pm - Derrick Henry finally getting some momentum, two runs to start this drive for 9 yards (Update: 15 yard personal foul penalty after the play on Julio Jones, 3rd and 16)
1:32pm - TOUCHDOWN CARDINALS!!! DeAndre Hopkins with the tip toe in the back of the end zone, incredible catch and landing from Murray!!! 10-0 start for the Cardinals!
1:30pm - Cardinals with their FOURTH penalty (29 yards) and another timeout. 2nd and Goal from the 5 yard line. Nearly an interception in the end zone on the Murray pass!
1:27pm - Review overturns the touchdown, 3-0 Cardinals, inside the 1 yard line
1:24pm - Chandler Jones with the weakside SACK & FORCED FUMBLE, touchdown Corey Peters!!!! 10-0 Cardinals (under review)
1:19pm - The Cardinals are the first on the board after a defensive stop and despite four penalties, 3-0 on the Matt Prater 34 yard field goal!
1:16pm - The Cardinals with FOUR bad penalties and an early timeout. Looking rusty and discombobulated, but they are in a position to score here on 2nd and Goal from the 24.
1:13pm - BOOM! DeAndre Hopkins with a massive 38 yard catch and run!
1:11pm - TEN first possession is a three and out. Punt to AZ for a quick 12 yard return. AZ Ball on the 39 yard line.
1:09pm - TEN first play from scrimmage, Derrick Henry runs left and is tripped up for a 3 yard loss.
12:50pm - Titans S Kevin Byard getting his defense ready for the Cardinals offense with stars Kyler Murray and DeAndre Hopkins!
12:38pm - J.J. Watt and the Cardinals are getting the crowd excited and hyped for the start of the season!
12:30pm - Cardinals Injury Report: Luq Barcoo (OUT), Tay Gowan (OUT), Joshua Miles (OUT), Chris Streveler (OUT), and Eno Benjamin (OUT)
Titans Injury Report: Tommy Hudson (OUT), Josh Reynolds (OUT), Dillion Radunz (OUT), Rashad Weaver (OUT), and Chris Jackson (OUT)
Murray and wide receiver Deandre Hopkins formed an impressive pair for the Cardinals last year, and they will look to build on that this season. Arizona bolstered its defense with the addition of Pro-Bowl pass rusher J.J. Watt from the Houston Texans.
For the Titans, Derrick Henry has been one of the best running backs in the NFL since his 2016 debut. Wide receiver A.J. Brown has emerged as the top target for quarterback Ryan Tannehill. The addition of Pro-Bowl receiver Julio Jones could help take the pressure off Brown and expand Tannehill's options.
No matter who comes out on top in this game, every viewer should be a winner as two of the top contenders in the NFL clash.
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