Washington opens the season April 6 at home against the New York Mets.
Stephen Strasburg has started Opening Day for the Nationals in each of the past three seasons.
Scherzer spent the last five seasons with the Detroit Tigers before signing a seven-year, $210 million deal with Washington during the offseason.
Scherzer, a two-time All-Star and the American League Cy Young Award winner in 2013, went 18-5 with a 3.15 ERA, 1.175 WHIP and 252 strikeouts in 220.1 innings pitched last season.
- Scooby Axson