You can follow the game with live stats and play-by-play here.
Details for Sunday's game are below:
Kickoff: 1 p.m. ET
Live stream: The game can be live streamed through NFL Sunday Ticket.
TV coverage: Fox
Odds: The Panthers are three-point favorites, according to Bovada, as of Friday.
Carolina has won four of the last five games against Detroit, most recently beating the Lions 31-22 in 2008.
In Newton's absence, Derek Anderson threw for 230 yards and two touchdowns in his first NFL start since 2010.
Defensive end Charles Johnson recently restructured his contract to give the team more cap room.
The Panthers are fifth in the NFL in total defense after Week 1, allowing 264 yards to Tampa Bay.
In his NFL debut, rookie wide receiver Kelvin Benjamin had six receptions for 92 yards and a touchdown.
Benjamin's 92 yards were the seventh-most for a rookie receiver in his first game since 2001.
Running back DeAngelo Williams dyed his hair pink against the Buccaneers in honor of his mother, who died in May after battling breast cancer.
Detroit won the last meeting between the teams, beating Carolina 49-35 in 2011.
Linebacker DeAndre Levy was named the NFC defensive player of the week after he had 10 tackles, two tackles for loss and an interception against the Giants.
Wide Receiver Calvin Johnson had 164 receiving yards in Week 1. It's the 13th time he's had 150 or more, which is three more times than any player since he entered the NFL in 2007.
The Lions honored late owner William Clay Ford with a pregame ceremony in Week 1.
Stafford had his 23rd 300-yard passing game since 2011, third-most in the NFL over that span. Stafford finished with 346 yards.
Rookie kicker Nate Freese made two of his three field-goal attempts in his NFL debut.
Defensive end George Johnson had 1.5 sacks against the Giants. They were the first sacks of his career.
The Lions are second in the NFL in total defense after holding New York to 197 total yards in Week 1.
- Ben Estes