Both Freeman and Jones are starters.
Freeman will miss his second straight game with a hamstring injury, while Jones remains out following a high ankle sprain he sustained in the Colts' loss to the Eagles Monday night.
Jones will reportedly miss 2-4 weeks due to the sprain.
Freeman had seven tackles and a forced fumble in the Colts' season opener, while Jones has six tackles on the season.
Sunday's game will be in Jacksonville. Both Indianapolis and the Jaguars are 0-2 on the season.
- Molly Geary