Coach Jim Caldwell said that when Bush -- who said he is "100 percent" -- returns to action, he will be the starter. The Lions host the Tampa Bay Buccaneers on Sunday.
Bush, 29, has missed the team's last three games after re-injuring his ankle against the Miami Dolphins in Week 10. He originally injured the ankle during Week 5 and has played in only seven games this season.
In his second season with the Lions, Bush has 191 rushing yards and 169 receiving yards. Last season, he set a career-high with 1,512 yards from scrimmage.
With Bush out of the lineup, Joique Bell has been the team's primary running back. He has 164 carries for 581 yards and five touchdowns, while also catching 23 passes for 218 yards.
Ankle injuries to Bush and star receiver Calvin Johnson have limited Detroit's offense, which ranks No. 17 in yards and No. 25 in points this season.
The Lions (8-4) have lost two of their last three games and are in second place in the NFC North. They host the Buccaneers on Sunday at 1 p.m.
- Paul Palladino