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NFL Week 5 odds: Giants favored at home against 49ers on Sunday night

The Giants enter the weekend as a touchdown favorite over the 49ers, according to sportsbooks monitored by OddsShark.com.

The NFL wraps up Week 5 Sunday action with an NFC matchup on Sunday Night Football, as the 2–2 Giants host the 1–3 49ers at MetLife Stadium.

The Giants enter the weekend as a touchdown favorite over the 49ers, according to sportsbooks monitored by OddsShark.com. The moneyline has the Giants between -280 and -300, and the 49ers between +235 and +250.

These two teams have extensive playoff history, with the winner going on to win the Super Bowl in six of their eight playoff meetinga. The Giants are 6–2 against the spread and 5–3 straight up in the last eight matchups between these two teams, according to the OddsShark NFL Database. The Giants are 3-2-1 ATS in their last six home games against the 49ers.

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The Giants are 2–2 SU but have gone 3–1 ATS so far in 2015. They are 2–5 SU in their last seven home games. They have been a touchdown favorite five times over the last three seasons. They were 5–0 SU and 3–2 ATS in those games.

The 49ers are 1–3 SU and ATS this season. They are 1–9 ATS in their last 10 games and 1–4 ATS in their last five road games. The 49ers have been a touchdown underdog three times over the last two seasons, going 0–3 SU and ATS in those situations.

The total, which is set at 43 points, has gone under in four of the last five games between these two teams and in five of the last seven meetings in New York. The total has gone under in eight of the 49ers’ last eleven games and over in four of the Giants’ last six.

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​The 49ers will be without outside linebacker Ahmad Brooks, who will miss the game due to a death in his family. Vernon Davis returned to practice in limited fashion this week after missing last week with a knee injury. His status is up in the air, but for now he is expected to play.

The Giants could be without several defensive players, as defensive end Robert Ayers, linebacker Devon Kennard, linebacker Jonathan Casillas and defensive end George Selvie have all missed practice this week. Their status is likely to be questionable, with Ayers the least likely to play on Sunday.