Hyde has been dealing with a stress fracture in his left foot and did not practice all week. San Francisco head coach Jim Tomsula originally stated at a press conference Friday that Hyde would be a game-time decision, but it was later reported that he will sit.
The second-year pro out of Ohio State ranks ninth in the NFL in rushing yards this season, with 470. Backup Reggie Bush will likely see an increased workload in Hyde’s absence.
The 49ers currently sit in last place in the NFC West with a 2–5 record. They will travel to St. Louis to face the Rams (3–3) on Sunday at 1 p.m. ET.
- Jeremy Layton