Johnson was listed as questionable after he missed practice on Friday, despite having two weeks to recover.
Johnson missed three games and portions of two games with an ankle sprain last season.
Through eight games, Johnson has led the Lions with 659 receiving yards on 48 receptions. He is also tied for the team lead in touchdown receptions (3).
Johnson has topped the 1000-yard receiving mark each of the last five seasons. Last season, he tallied 1077 yards, his lowest total since 2009.