Brown sustained a concussion in last week’s wild-card victory over the Cincinnati Bengals on a hard hit by linebacker Vontaze Burfict. Burfict has since been suspended for the first three games of the 2016 season.
The 27-year-old Brown led the league with 136 receptions this season, while also leading the Steelers with 1,834 receiving yards and 10 touchdowns.
The Steelers and Broncos are scheduled to kick off at 4:40 p.m. ET on Sunday.
- Erin Flynn