Universidad de Chile defeated Internacional of Brazil 1-0 in Santiago, and in doing so qualified for the quarterfinals of the Copa Sudamericana by knocking out the defending champions.
The only goal of the match was scored by Uruguayan striker Juan Manuel Olivera in the first half.
Universidad claimed a 1-1 draw in Porto Alegre last week and this put it in a favorable position ahead of the second leg.
The Chileans dominated the first half, and created several clear-cut opportunities to take the lead.
After much pressure, they finally went in front in the 36th minute when the always reliable Olivera connected to a Walter Montillo free kick with a perfect header.
River Plate proved too strong for Vitoria of Brazil, turning a 1-1 draw into a 5-2 aggregate victory over the two legs.
The Uruguayans came into the game with a commanding 4-1 advantage after the first leg result in Montevideo last week, but they were put under heavy pressure by Vitoria in the early moments of the match.
The Brazilians pushed to the attack with lots of men, but wasted several clear-cut opportunities in the first half.
Finally, in the 86th minute, substitute Elkeson De Oliveira put the Brazilians ahead with a long-distance thunderbolt. But the goal came much too late.
In second half injury-time, Jorge Cordoba finished off a fast break away to earn River a draw.
San Lorenzo proved too strong for Cienciano with a comfortable 2-0 win in Cusco, Peru. Diego Simeone's side claimed a 5-0 aggregate victory over the two legs.
The Argentine outfit played a very intelligent game and won the match courtesy of goals from Cristian Gonzalez and Gonzalo Rovira.
Cienciano pushed to the attack straight from the kick-off and could have taken the lead in the 7th minute had Maurico Montes taken advantage of a clear-cut goal-scoring opportunity.
The Peruvians dominated their opponents, but although they played the better football they couldn't penetrate the visiting defense.
San Lorenzo will face River Plate of Uruguay in the quarter-finals of the competition.