49ers vs. Seahawks Best NFL Prop Bets and Anytime Touchdown Scorer Picks for NFL Week 1

Bet on George Kittle to score a touchdown in Week 1 against the Seahawks.
Bet on George Kittle to score a touchdown in Week 1 against the Seahawks. / Stephen R. Sylvanie-Imagn Images

The San Francisco 49ers and Seattle Seahawks are set to face each other in an NFC West duel to begin their respective 2025 NFL seasons.

The news of the day will be whether or not Christian McCaffrey will suit up after being added to the injury list on Thursday. Whether or not he plays may change the chances of either team winning, but we can still attack the props market with full confidence. Let's take a look at my top prop plays for Sunday's showdown.

49ers vs. Seahawks Best NFL Prop Bets

Ricky Pearsall OVER 40.5 Receiving Yards (-115)

I'm high on Ricky Pearsall this season. He thrived last year when given the opportunity, including racking up 14 receptions for 210 yards and two touchdowns in the 49ers' final two games. Now, with Brandon Aiyuk sidelined for at least this week, I expect Pearsall to get plenty of looks against the Seahawks.

Kenneth Walker OVER 2.5 Receptions (+110)

Not enough people are talking about involving Kenneth Walker was involved in the Seahawks' passing game last season. He averaged 4.18 receptions per game last season, racking up 299 yards through the air. Despite that, we can bet on him at +110 odds to record just three catches for Seattle on Sunday. As long as his 2024 numbers carry over to 2025, this is going to look like a great bet come Sunday.

George Kittle Anytime Touchdown (+170)

Let's not forget that George Kittle is a touchdown machine. He caught eight touchdowns in 15 games last season. Now, with a healthy offense supporting him and the passing game, I expect him to have another big season, especially when it comes to finding the end zone. His scoring on Sunday at +170 is a solid touchdown bet to place.


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Iain MacMillan
IAIN MACMILLAN

Originally from Nova Scotia, Iain MacMillan is a senior editor covering betting, with a focus on NFL, NHL, and golf. He hosts the Bacon Bets Podcast and has been featured on VSIN, BetQL and Monumental Sports Network. He is a member of the Metropolitan Golf Writers Association and his beloved Falcons and Maple Leafs break his heart on a yearly basis.