NFL Straight-Up Moneyline Picks for Every Game in Week 16

Iain MacMillan | 1 Hour Ago

The Sports Illustrated team gives their picks for all 16 games in Week 16. / Sports Illustrated

Week 15 of the 2025 NFL season is in the books, which means we have just three weeks to go before the postseason officially begins. Last week, Mitch Goldich, Conor Orr, and Iain MacMillan were the three SI panelists to walk away with a profitable record. Still, Orr and Matt Verderame are the only two who are in the green for the entire season.

There's still some time for the other six panelists to make a run at getting back in the green, so let's take a look at everyone's pick to win all 16 NFL Week 16 games.

Week 15 Results

• Clare Brennan, Associate Editor 9-7 (-3.32 units)
• Mitch Goldich, Senior Editor 11-5 (+1.22 units)
• Gilberto Manzano, NFL Staff Writer 9-7 (-2.99 units)
• Conor Orr, Senior Writer 11-5 (+1.02 units)
• John Pluym, NFL Managing Editor 7-9 (-7.69 units)
• Matt Verderame, NFL Staff Writer 10-6 (-1.45 units)
• Iain MacMillan, Senior Editor, Betting 10-6 (+0.82 units)
• Peter Dewey, Associate Managing Editor, Betting 9-7 (-3.98 units)

Season-to-Date Results

• Clare Brennan, Associate Editor 144-79-1 (-6.58 units)
• Mitch Goldich, Senior Editor 144-79-1 (-4.89 units)
• Gilberto Manzano, NFL Staff Writer 132-101-1 (-19.34 units)
• Conor Orr, Senior Writer 148-75-1 (+15.37 units)
• John Pluym, NFL Managing Editor 135-88-1 (-20.84 units)
• Matt Verderame, NFL Staff Writer 151-72-1 (+4.74 units)
• Iain MacMillan, Senior Editor, Betting 132-91-1 (-9.65 units)
• Peter Dewey, Associate Managing Editor, Betting 140-84-1 (-12.81 units)

NFL Week 16 Picks

NFL Week 16 Picks / Sports Illustrated

All odds via BetMGM Sportsbook

Rams (-110) vs. Seahawks (-110)

• Clare Brennan: Rams
• Mitch Goldich: Seahawks
• Gilberto Manzano: Rams
• Conor Orr: Rams
• John Pluym: Rams
• Matt Verderame: Rams
• Iain MacMillan: Rams
• Peter Dewey: Rams

Eagles (-285) vs. Commanders (+230)

• Clare Brennan: Eagles
• Mitch Goldich: Eagles
• Gilberto Manzano: Eagles
• Conor Orr: Eagles
• John Pluym: Eagles
• Matt Verderame: Eagles
• Iain MacMillan: Eagles
• Peter Dewey: Eagles

Packers (-118) vs. Bears (-102)

• Clare Brennan: Packers
• Mitch Goldich: Bears
• Gilberto Manzano: Bears
• Conor Orr: Bears
• John Pluym: Packers
• Matt Verderame: Packers
• Iain MacMillan: Packers
• Peter Dewey: Bears

Jets (+185) vs. Saints (-225)

• Clare Brennan: Saints
• Mitch Goldich: Saints
• Gilberto Manzano: Saints
• Conor Orr: Saints
• John Pluym: Saints
• Matt Verderame: Saints
• Iain MacMillan: Saints
• Peter Dewey: Saints

Bills (-600) vs. Patriots (+425)

• Clare Brennan: Bills
• Mitch Goldich: Bills
• Gilberto Manzano: Bills
• Conor Orr: Bills
• John Pluym: Bills
• Matt Verderame: Bills
• Iain MacMillan: Bills
• Peter Dewey: Bills

Chiefs (-190) vs. Titans (+155)

• Clare Brennan: Chiefs
• Mitch Goldich: Chiefs
• Gilberto Manzano: Chiefs
• Conor Orr: Titans
• John Pluym: Chiefs
• Matt Verderame: Titans
• Iain MacMillan: Chiefs
• Peter Dewey: Titans

Chargers (+105) vs. Cowboys (-125)

• Clare Brennan: Chargers
• Mitch Goldich: Chargers
• Gilberto Manzano: Chargers
• Conor Orr: Chargers
• John Pluym: Chargers
• Matt Verderame: Chargers
• Iain MacMillan: Cowboys
• Peter Dewey: Chargers

Vikings (-150) vs. Giants (+125)

• Clare Brennan: Vikings
• Mitch Goldich: Vikings
• Gilberto Manzano: Vikings
• Conor Orr: Vikings
• John Pluym: Vikings
• Matt Verderame: Vikings
• Iain MacMillan: Vikings
• Peter Dewey: Vikings

Buccaneers (-155) vs. Panthers (+130)

• Clare Brennan: Buccaneers
• Mitch Goldich: Buccaneers
• Gilberto Manzano: Panthers
• Conor Orr: Buccaneers
• John Pluym: Panthers
• Matt Verderame: Panthers
• Iain MacMillan: Panthers
• Peter Dewey: Panthers

Bengals (-140) vs. Dolphins (+118)

• Clare Brennan: Dolphins
• Mitch Goldich: Dolphins
• Gilberto Manzano: Bengals
• Conor Orr: Bengals
• John Pluym: Dolphins
• Matt Verderame: Dolphins
• Iain MacMillan: Bengals
• Peter Dewey: Bengals

Jaguars (+135) vs. Broncos (-160)

• Clare Brennan: Broncos
• Mitch Goldich: Broncos
• Gilberto Manzano: Broncos
• Conor Orr: Broncos
• John Pluym: Jaguars
• Matt Verderame: Broncos
• Iain MacMillan: Broncos
• Peter Dewey: Broncos

Falcons (-140) vs. Cardinals (+118)

• Clare Brennan: Falcons
• Mitch Goldich: Falcons
• Gilberto Manzano: Falcons
• Conor Orr: Falcons
• John Pluym: Falcons
• Matt Verderame: Falcons
• Iain MacMillan: Falcons
• Peter Dewey: Falcons

Raiders (+800) vs. Texans (-1400)

• Clare Brennan: Texans
• Mitch Goldich: Texans
• Gilberto Manzano: Texans
• Conor Orr: Texans
• John Pluym: Texans
• Matt Verderame: Texans
• Iain MacMillan: Texans
• Peter Dewey: Texans

Steelers (+275) vs. Lions (-350)

• Clare Brennan: Lions
• Mitch Goldich: Lions
• Gilberto Manzano: Lions
• Conor Orr: Lions
• John Pluym: Lions
• Matt Verderame: Lions
• Iain MacMillan: Lions
• Peter Dewey: Lions

Patriots (+125) vs. Ravens (-150)

• Clare Brennan: Patriots
• Mitch Goldich: Patriots
• Gilberto Manzano: Patriots
• Conor Orr: Patriots
• John Pluym: Ravens
• Matt Verderame: Patriots
• Iain MacMillan: Patriots
• Peter Dewey: Ravens

49ers (-275) vs. Colts (+225)

• Clare Brennan: 49ers
• Mitch Goldich: 49ers
• Gilberto Manzano: 49ers
• Conor Orr: 49ers
• John Pluym: 49ers
• Matt Verderame: 49ers
• Iain MacMillan: Colts
• Peter Dewey: 49ers

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