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Week 6 college football odds: Lines, spreads for biggest games

The Arizona Wildcats are 4-12 SU and 6-10 ATS in their last 16 road games against Pac-12 opponents. Arizona will be a big road underdog Thursday night when the Wildcats visit the No. 2 Oregon Ducks.

Oregon enters Thursday’s game as a 23.5-point home favorite, according to sportsbooks monitored by OddsShark.com. The Ducks are just 2-7 ATS in their last nine games overall and 3-6 ATS in their last nine games against Arizona.

The Arizona State Sun Devils visit the No. 16 USC Trojans on Saturday in a game that could end up being a high-scoring one. The OVER is 3-1 in the last four games between USC and ASU and 12-4-1 in Arizona State's last 17 road games against Pac-12 opponents. The total for Saturday's game is set at 66 points and USC is a 12-point favorite at home.

The East Carolina Pirates are likely to be a popular pick Saturday even as a huge chalk favorite. The Pirates are a 41-point favorite at home against the SMU Mustangs at sportsbooks monitored by OddsShark.com. East Carolina is 8-1 ATS over its last nine games and SMU is 4-13 ATS in its last 17 games as a road underdog. The Mustangs are 0-4 SU and ATS this season and have been outscored 202-12 over those four games.

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The No. 1 Florida State Seminoles host the Wake Forest Demon Deacons on Saturday and are still looking for their first cover of the season with an 0-5 ATS record over their last five games. The Seminoles are a 39.5-point favorite despite their recent struggles. Trends point to the UNDER in this matchup. The UNDER is 19-5 in Wake Forest's last 24 games and 5-2 in Florida State's last seven games.

No. 4 Oklahoma could be a good value pick at only -5 this week visiting the No. 25 TCU Horned Frogs. Oklahoma is 4-1 ATS in its last five games as a road favorite and 3-0 ATS in its last three games against conference opponents. TCU on the other hand is just 1-7 ATS in its last eight games against Big 12 foes.

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