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College football Week 10 odds: Betting lines for biggest matchups

The Week 10 college football slate is highlighted by Ohio State-Nebraska and Alabama-LSU. Here's an early look at the odds for all of the top matchups on Saturday.

The Ohio State Buckeyes are 18–1 straight up in their last 19 home games against Big Ten opponents, but are just 2–7 against the spread over their last nine. The Buckeyes will try to put together a strong performance at home this Saturday when they host the Nebraska Cornhuskers.

Ohio State is a 17-point home favorite on the college football lines at sportsbooks monitored by OddsShark.com. Since starting the season off 4–0 SU and ATS, the Buckeyes have been a lot less dominant over their last four games, going 3–1 SU and 0–4 ATS. Each of Ohio State's last three games have been decided by a touchdown or less.

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Nebraska is 8–1 ATS in its last nine games coming off a loss in the previous game of a matchup, which it had in its last game against the Buckeyes.

After being favored by at least 10 points in every other game this season, the Alabama Crimson Tide are just 7.5-point favorites this Saturday on the road against the LSU Tigers.

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Both teams come into this game off a bye week. While the week off could be an advantage for Nick Saban on the sidelines, it was an advantage for LSU on the field as it gave Leonard Fournette some more time to rest and get healthy. Alabama has won each of its last nine games on the road against teams with winning records.

Two of the top 15 scoring offenses in the country will collide on Saturday when the Washington Huskies visit the Cal Bears as 16.5-point road favorites. Washington's Jake Browning is tied for third in the nation in touchdown passes with 28, but he sits behind Cal's Davis Webb in that category as the Bears' senior quarterback has 29 so far in 2016.

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Cal is just 1–6 SU and 2–5 ATS in its last seven games against the Huskies per the OddsShark College Football Database.

While teams like Alabama and Texas A&M in the SEC West have been earning the headlines, the Florida Gators have quietly played their way into the No. 10 ranking in the AP Top 25 with a 6–1 SU and 3–4 ATS record. The Gators are 8–0 SU and 7–1 ATS in their last eight games against Arkansas, and they'll be on the road against the Razorbacks this Saturday as 5.5-point favorites.