Score Prediction Signals Tough Penn State Test For Oregon, Dan Lanning

The Oregon Ducks will be on the road to take on the Penn State Nittany Lions on Saturday, Sep. 27. It will be a hostile white-out crowd of over 100,000 fans in attendance. Will Dan Lanning be able to knock off James Franklin for the second time in as many years?

Oregon head coach Dan Lanning looks on as the Oregon Ducks host the Montana State Bobcats on Aug. 30, 2025, at Autzen Stadium in Eugene, Oregon. | Ben Lonergan/The Register-Guard / USA TODAY NETWORK via Imagn Images

The Oregon Ducks will travel to the east coast this week to take on the Penn State Nittany Lions. This matchup between the No. 6 ranked Ducks and No. 3 ranked Nittany Lions is the college football game of the week and will be the host of ESPN’s College GameDay show. 

Will Oregon come away with a road win in front of the white-out crowd at Beaver Stadium?

Oregon vs. Penn State Preview, FPI Prediction

Oregon Ducks head coach Dan Lanning calls to his team during a timeout as the Oregon Ducks host the Oregon State Beavers Sept. 20, 2025, at Autzen Stadium in Eugene, Oregon. | Ben Lonergan/The Register-Guard / USA TODAY NETWORK via Imagn Images

ESPN’s Football Power Index gives Oregon a 48.9 percent chance to defeat Penn State. 

Oregon has gotten off to a perfect 4-0 start this season with blowout wins over the Montana State Bobcats, Oklahoma State Cowboys, Northwestern Wildcats, and Oregon State Beavers. Penn State will be by far their biggest challenge so far and might even end up being their toughest game of the entire season. 

Oregon quarterback Dante Moore is off to great start throwing for 962 yards and 11 touchdowns with just one interception. Penn State quarterback Drew Allar has thrown for 626 yards, four touchdowns, and one interception. 

Sep 13, 2025; University Park, Pennsylvania, USA; Penn State Nittany Lions quarterback Drew Allar (15) drops back in the pocket while looking to throw a pass during the second quarter against the Villanova Wildcats at Beaver Stadium. Mandatory Credit: Matthew O'Haren-Imagn Images | Matthew O'Haren-Imagn Images

A lot like Oregon, Penn State has not been tested this season. The Nittany Lions are 3-0 and have wins over the Nevada Wolfpack, FIU Panthers, and Villanova Wildcats. 

Both of these teams made the College Football Playoff last year. They came into 2025 with expectations of getting back and challenging to win the national championship. 

These two teams last played in the 2024 Big Ten Championship game. Oregon came out victorious with a 45-37 win. 

MORE: James Franklin’s Eye-Opening Quotes About Oregon From 41-Minute Penn State Presser

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MORE: Early Score Prediction For Oregon vs. Penn State Might Surprise Some

Oregon vs. Penn State Betting Odds

Oregon Ducks running back Jordan James (20) celebrates a touchdown Saturday, Dec. 7, 2024, during the Big Ten Championship game between the Oregon Ducks and the Penn State Nittany Lions at Lucas Oil Stadium in Indianapolis. | Grace Smith/IndyStar / USA TODAY NETWORK via Imagn Images

Oregon is a 3.5 point road underdog at Penn State with odds of +145 to win outright according to DraftKings Sportsbook. Penn State is -175 to win the game. 

The over/under is currently at 51.5 points. 

Oregon vs. Penn State Score Prediction 

Nov 9, 2024; University Park, Pennsylvania, USA; Fireworks burst overhead as the Penn State Nittany Lions take the field prior to a White Out game against the Washington Huskies at Beaver Stadium. Mandatory Credit: Matthew O'Haren-Imagn Images | Matthew O'Haren-Imagn Images

This would arguably be Dan Lanning’s best win since taking over as Oregon coach in 2022. The Nittany Lions boast one of the best home field advantages in the entire country and are one of the biggest favorites to win the national title. Lanning has some big wins already with Oregon including over Penn State in the Big Ten title game, but this would be right up there.

Penn State coach James Franklin has struggled in his games against top 10 teams, with a record of 4-20. He can shake off the narrative that his team can’t win big games if they can take down the No. 6 ranked Ducks. 

Dante Moore will be making his most difficult start as a Duck and it comes on the road in front of 100 thousand people. It’s a tall order. Penn State has more experience at this point and are at home. This gives the Nittany Lions a slight edge. Oregon looses a close one, but will cover the spread.

Penn State 27, Oregon 24

• Game odds refresh periodically and are subject to change. 
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