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Oregon head coach Dan Lanning takes the field as the Oregon Ducks host the Portland State Vikings on Sept. 18, 2026, at Autzen Stadium in Eugene, Oregon.

The No. 20 Oregon Ducks could be without several key stars in their high-stakes Big Ten clash against the No. 12 USC Trojans at the Los Angeles Memorial Coliseum on Saturday.

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The No. 20 Oregon Ducks could be without several key stars in their high-stakes Big Ten clash against the No. 12 USC Trojans at the Los Angeles Memorial Coliseum on Saturday.

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The Oregon Ducks open Big Ten play with a heavyweight showdown, and needing these battles to play into their favor.

Nov. 11, 2023; Eugene, Oregon, USA; Oregon Ducks coach Dan Lanning breaks from a huddle during the team's 2023 matchup against the USC Trojans at Autzen Stadium

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No. 20 Ducks take their rebuilt offense on the road for a Big Ten showdown versus the No. 12 Trojans.

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These five Oregon Ducks have a chance to make the biggest impact on Saturday against the USC Trojans.

Jan 1, 2025; Pasadena, California, USA; Kirk Herbstreit on the ESPN Gameday set at Rose Bowl Stadium. Mandatory Credit: Kirby Lee-Imagn Images

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Kirk Herbstreit still believes in coach Dan Lanning and the Oregon Ducks, but says the Ducks' first two games "reeked of individuality and not respecting your opponent."

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Penn State Nittany Lions transfer Andrew Olesh has started the Oregon Ducks' last two bouts at the Oklahoma State Cowboys and against the Portland State Vikings.

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The Oregon Ducks have more than just the famed "stormtrooper" look against the USC Trojans on Sept. 26.

Oregon head coach Dan Lanning walks the field before the game during the Oregon Ducks annual spring game on April 25, 2026 at Autzen Stadium in Eugene, Oregon.

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The Oregon Ducks didn't see any surprises on their second injury report ahead of a matchup against the USC Trojans.

Oregon head coach Dan Lanning speaks during a press conference on Aug. 18, 2026, at the Hatfield-Dowlin Complex in Eugene, Oregon.

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Oregon Ducks coach Dan Lanning addressed the impact that the Bidwell family has on the program after Brady Bidwell's touchdown against Portland State

Nov 11, 2023; Eugene, Oregon, USA; USC Trojans head coach Lincoln Riley, left, and Oregon Ducks head coach Dan Lanning talk before a game at Autzen Stadium.

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The Oregon Ducks vs. USC Trojans matchup is full of storylines, but which ones will impact the game?

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Coach Dan Lanning and the Oregon Ducks appear to be gaining ground with another blue-chip quarterback recruit in the 2028 class.

Nov 14, 2025; Eugene, Oregon, USA; Oregon Ducks wide receiver Dakorien Moore watches teammates warm up before a game against the Minnesota Golden Gophers at Autzen Stadium.

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Wid receiver Jeremiah McClellan's absence creates bigger opportunities for three Oregon Ducks receivers against No. 12 USC.

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Oregon tight end Andrew Olesh discusses his growing role, Dante Moore's leadership and Saturday's rivalry matchup versus the Trojans.

Jan 1, 2025; Pasadena, CA, USA; Oregon Ducks head coach Dan Lanning speaks in a press conference after the game against the Ohio State Buckeyes in the 2025 Rose Bowl college football quarterfinal game at Rose Bowl Stadium. Mandatory Credit: Kirby Lee-Imagn Images

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The Oregon Ducks and USC Trojans enter Saturday’s rivalry game with identical College Football Playoff odds, but the loser will face a steep climb to the CFP.

Oregon head coach Dan Lanning, left, talks to Oregon offensive lineman Dave Iuli as the Oregon Ducks host the Portland State Vikings on Sept. 18, 2026, at Autzen Stadium in Eugene, Oregon.

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Here’s everything to know ahead of the Oregon Ducks’ matchup with the USC Trojans, including how to watch, betting odds, and preview.

Oregon wide receiver Jeremiah McClellan walks on the field in a boot as the Oregon Ducks host the Portland State Vikings on Sept. 18, 2026, at Autzen Stadium in Eugene, Oregon.

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The Oregon Ducks' first Big Ten injury report featured anticipated players ahead of a top-25 battle against the USC Trojans.

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The No. 20 Oregon Ducks are wearing all-white uniforms on the road against the No. 12 USC Trojans.

Oregon head coach Dan Lanning looks on as the Oregon Ducks face the Oklahoma State Cowboys on Sept. 12, 2026, at Boone Pickens Stadium in Stillwater, Oklahoma.

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Oregon’s offensive line faces its biggest test since Oklahoma State against No. 12 USC, giving Ducks tackle Fox Crader a chance to prove himself.

Oregon quarterback Dante Moore speaks during a press conference on Aug. 18, 2026, at the Hatfield-Dowlin Complex in Eugene, Oregon.

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Oregon Ducks quarterback Dante Moore's changed leadership could play a major role in the team's Week 4 road showdown against the No. 12 USC Trojans.

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The Oregon Ducks will aim to impress their recruiting class against USC, yet suddenly must win back one prized verbal commitment following an SEC visit.

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Oregon Ducks coach Dan Lanning covered everything from Phil Knight's latest donation to the Bidwell family legacy in his latest press conference.

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The Oregon Ducks' wide receiver core must operate without Jeremiah McClellan and against a deep USC Trojans secondary.

July 27, 2024; Eugene, OR, USA; Kendre Harrison part of the top-ranked recruits flocked to Eugene for the 2024 Oregon Ducks Saturday Night Live ; Mandatory credit: Zachary Neel-USA TODAY NETWORK via Imagn Images

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Three Oregon Ducks freshmen earned top grades on offense in Week 3 as they look to develop bigger roles.

Sep 5, 2026; Eugene, Oregon, USA; The Oregon cheer team perform for fans before a game between the Oregon Ducks and the Boise State Broncos at Autzen Stadium. Mandatory Credit: Troy Wayrynen-Imagn Images

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Oregon travels to play the USC Trojans and here is everything Ducks fans should know ahead of the Big Ten rivalry game, including the latest Los Angeles weather forecast, TV information and pregame quotes from coach Dan Lanning.

Sept. 18, 2026; Eugene, Oregon, USA; Oregon Ducks quarterback Dante Moore celebrates with teammates after the Ducks 84-0 win over Portland State at Autzen Stadium.

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Oregon Ducks signal-caller eyes encore against No. 12 USC after four-touchdown performance.