Atletico Madrid could be without four senior centre-backs when they face Barcelona in La Liga in two weeks.
Diego Godin, Jose Giminez, Lucas Hernandez and Stefan Savic will all be fighting to prove their fitness when Ernesto Valverde's side visit the Wanda Metropolitano Stadium after the international break.
Diego Simeone's side defeated Athletic Bilbao 3-2 on home soil over the weekend, with Godin netting a stoppage-time winner.
But it is said that the Uruguay international is now almost certain to miss the Barca encounter after the club confirmed that he suffered a muscle injury to his left thigh.
There is also no timescale on Godin's international teammate Giminez, who suffered his fourth muscle injury of the season against Borussia Dortmund in the Champions League last Tuesday.
It is said that if Simeone is to have any centre-backs fit for the Barca clash then Hernandez and Savic will be the two likeliest of players to start.
Simeone's side have begun their La Liga season in a positive fashion as they currently sit one point behind leaders Barcelona in the table.
In Europe, they are second in Group A, level on points with German giants Dortmund and five points ahead of third-placed Club Brugge with two games left to play.
The major positive for Atleti is that their current crop of injured defenders will have some time to heal over the international break.