Kelly was injured while fielding a ground ball in the third inning and Mathis was hurt after taking a foul tip to the hand in the eighth inning.
Kelly, a utilityman who played first base, third base and all three outfield positions for the Tigers last year, is a backup at multiple positions for the Marlins. Mathis is the second-string catcher behind Jarrod Saltalamacchia. Miami will have to call up another catcher from the minors to replace Mathis.
Kelly, 35, batted .245 with a .620 OPS last season for the Tigers. He signed a one-year deal with the Marlins this winter after six seasons in Detroit.
Mathis was Miami's primary catcher in 2013 and backed up Saltalamacchia last season. In 139 career games with the Marlins he has a .188 batting average and .535 OPS.
- Dan Gartland