The third-inning home run to left-centerfield gave the Cubs a 1-0 lead over the Brewers in the first game of the series.
After that at bat, Russell was batting .207 with a home run and six RBIs.
Russell was called up by the Cubs on April 21 and went 0-5 with three strikeouts in his debut. The 21-year-old was drafted by the Oakland A's with the 11th pick in the 2012 MLB draft. The Cubs acquired Russell last season in a trade involving pitchers Jeff Samardzija and Jason Hammel. The A's also got outfielder Bill McKinney and pitcher Dan Straily in the deal. Hammel is now back with the Cubs.
Though Russell has played primarily shortstop in the minors, he is starting at second for the Cubs because the team has All-Star shortstop Starlin Castro.