Wade has missed the Heat's last seven games due to a hamstring injury sustained during a Jan. 27 loss to the Milwaukee Bucks.
He sat out Sunday's All-Star Game due to the injury as well, saying he could play, but "it would not be the smart thing to do."
"The break did me good," Wade said on Wednesday. "I feel like I'll be playing on Friday. A hundred percent? You all can quit that."
Wade said he'll be "ready to go" and that his conditioning is the concern, not his hamstring.
In 35 games this season, Wade has averaged 21.4 points, 5.4 assists and 3.8 rebounds while shooting 48.7 percent from the field.
Miami (22-30) is currently in eighth place in the Eastern Conference and plays the New York Knicks on Friday.
- Molly Geary