Milliner sustained a high left ankle sprain in practice on Aug. 10 and has not returned to the field since. He was ruled questionable for Week 1 at the time. On Wednesday, Milliner said he wasn't sure if he could play Sunday, and it was reported that Ryan had already all but ruled the cornerback out.
The No. 9 pick in the 2013 NFL draft, Milliner had 56 tackles and three interceptions for the Jets in his rookie season while making 12 starts.
The Jets will likely start backup Darrin Walls in Milliner's place alongside Antonio Allen, who was converted to cornerback from safety. Rookie Dexter McDougle was ruled out for the season after he tore his ACL in August.
New York opens the season against the Oakland Raiders at home.
- Ben Estes