Watkins fully participated in practice on Wednesday after re-injuring his ribs in a preseason game against the Lions last Thursday. Coach Doug Marrone did not say whether Watkins will play, but NFL.com's Ian Rapoport reported last week that Watkins "should be good to go."
Watkins left the game against Detroit midway through the first quarter after absorbing a hit from linebacker Ashlee Palmer. Watkins first injured his ribs against the Steelers on Aug. 16 and was held out of the Bills' Aug. 23 game against the Tampa Bay Buccaneers.
Watkins, 21, caught 101 passes for 1,464 yards and 12 touchdowns in his final season at Clemson. Buffalo traded the No. 9 pick as well as its first and fourth-round picks in 2015 to move up and select him at No. 4.
Cornerback Stephon Gilmore, who is listed as a starter on the team's depth chart, is questionable for Sunday with groin soreness. Gilmore said earlier this week that he won't have any issues playing in the game.
- Chris Johnson