Orton is in his 10th NFL season. He last played more than five games in a season in 2010 with the Denver Broncos.
The Bills started the season 2-2 behind quarterback EJ Manuel. This season, Manuel has completed 76-of-131 passes for 838 yards, five touchdowns and three interceptions.
Before coming to Buffalo, Orton played for the Dallas Cowboys. He started for the Cowboys in a must-win Week 17 game against the Eagles last season in place of injured Tony Romo, but Dallas was denied a playoff berth with a 24-22 home defeat.
Orton has a career 4-0 record against the Lions, throwing for 822 yards, four touchdowns and no interceptions. In his last game against Detroit, Orton
- Sarah Barshop