Alford, 26, broke his wrist in Week 11, but the team was hopeful he would be able to return without needing surgery.
The Falcons drafted Alford in the second round of the 2013 draft, and he started all ten of the games he played in this season. He had 31 tackles, 11 passes defended and three interceptions this season.
Atlanta is No. 32 against the pass this season and also No. 32 in total yards allowed. The Falcons have lost two straight games and three of their last four.
Atlanta closes the regular season with a road game against the Saints on Sunday and a home date with the Panthers on Dec. 28.
- Paul Palladino