Locker will step away from the game after four NFL seasons, all of which were with the Tennessee Titans. The 26-year-old former Washington Huskies standout was selected No. 8 overall by Tennessee in the 2011 draft.
Locker said in his statement:
"I am retiring from football after much reflection and discussion with my family. I will always be grateful for having had the opportunity to realize my childhood dream of playing in the NFL and for the lifelong relationships I developed because of that experience.
"Football has always played a pivotal role in my life and I love the game, but I no longer have the burning desire necessary to play the game for a living; to continue to do so would be unfair to the next organization with whom I would eventually sign.
"I realize this decision is surprising to many, but I know in my heart that it is the right decision and I look forward to spending more time with my family and pursuing other interests."
Locker's 2014 season was cut short due to a dislocated shoulder and he was placed on injured reserve in December. He previously missed time last season due to a thumb injury and was benched in favor of Zach Mettenberger in October.
In seven games last season, Locker threw for 993 yards, five touchdowns and seven interceptions. He ends his career having completed 57.5% of his passes for 4,967 yards, 27 touchdowns and 22 interceptions.
- Molly Geary