McCoy, 27, is entering his first season with the Bills. Buffalo acquired the running back in a trade with the Philadelphia Eagles this off-season in exchange for linebacker Kiko Alonso. Last year, McCoy ran for 1,319 yards and five touchdowns.
Behind McCoy on the Bills’ depth chart at running back are Karlos Williams and Boobie Dixon, who are listed as probable for the season opener. Williams, a fifth-round pick, battled his own injuries during camp. Buffalo released veteran running back Fred Jackson in August.
Bills coach Rex Ryan said McCoy was “ready to roll” after practice Wednesday.
Buffalo opens its season on Sunday against the Indianapolis Colts.
– Rohan Nadkarni