He was replaced by Carlos Torres after finishing a scoreless first inning.
Matsuzaka came to the mound late, pushing the 1:10 p.m. ET start time back a few minutes. He walked two batters in the inning, and was visited by manager Terry Collins and a trainer after the second.
The 33-year-old is 3-0 with a 2.88 ERA in 20 games this season, and Sunday was his fourth start. He is 56-40 with a 4.44 ERA in his career — six seasons with the Red Sox and two with the Mets.
The Mets, who entered the game 30-38, had only four relievers available for Sunday's game.
Update: Daisuke Matsuzaka left today's game with a severe upset stomach. — New York Mets (@Mets) June 15, 2014