Giants vs. Diamondbacks Prediction, Odds, Probable Pitchers and Prop Bets for Wednesday, Sept. 17

The Giants and D-Backs are battling fo a wild card spot on Wednesday.

San Francisco Giants starting pitcher Justin Verlander has a 2.44 ERA since the All-Star break. / Darren Yamashita-Imagn Images

Both the Arizona Diamondbacks and San Francisco Giants are battling for the final wild card spot in the National League heading into Wednesday’s matinee matchup.

Arizona (77-75) is just 1.5 games behind the New York Mets in the standings and currently has the best odds to overtake New York in the wild card race. The Giants, meanwhile, are three games back of New York and one game under .500 heading into Wednesday's matchup. 

Still, oddsmakers at the best betting sites essentially have this game set as a pick’em on Wednesday.

Justin Verlander (3.94 ERA) gets the ball for the Giants against Arizona’s Brandon Pfaadt (5.31 ERA), who is a pitcher that I’m looking to fade when it comes to the prop market today.

Here’s a breakdown of the odds, my favorite prop and a prediction for this NL West battle.  

Giants vs. Diamondbacks Odds, Run Line and Total

Odds via DraftKings Sportsbook

Run Line

• Giants -1.5 (+143)
• D-Backs +1.5 (-176)

Moneyline

• Giants: -108
• D-Backs: -112

Total

• 9 (Over -105/Under -115)

Giants vs. Diamondbacks Probable Pitchers

• San Francisco: Justin Verlander (3-10, 3.94 ERA)
• Arizona: Brandon Pfaadt (13-8, 5.31 ERA)

Giants vs. Diamondbacks How to Watch

• Date: Wednesday, Sept. 17
• Time: 3:40 p.m. EST
• Venue: Chase Field
• How to Watch (TV): MLB Network, ARID, NBCS-BA
• Giants record: 75-76
• D-Backs record: 77-75

Giants vs. Diamondbacks Best MLB Prop Bets

Giants Best MLB Prop Bet

• Rafael Devers to Hit a Home Run (+495)

Earlier today, I shared in SI Betting’s best home run picks – Daily Dinger – why Devers is undervalued at this price:

Yes, Rafael Devers has struggled as of late for the San Francisco Giants, hitting just .159 over the last two weeks, but I believe that he’s mispriced in this market on Wednesday afternoon.

Devers is facing Arizona Diamondbacks righty Brandon Pfaadt, who has given up 24 home runs in 30 appearances this season while posting a shaky 5.31 ERA. On top of that, the D-Backs have the fourth-worst bullpen ERA (4.76) backing him up.

That sets up well for Devers, who has hammered right-handed pitching to the tune of a .890 OPS and 22 of his 31 homers in 2025. 

For a player that already has eclipsed 30 homers, getting Devers at nearly 5/1 is worth a shot in this matchup. 

Giants vs. Diamondbacks Prediction and Pick

Overall, the Giants have struggled in Verlander’s outings this season, but the veteran right-hander has been a much better pitcher since the All-Star break, posting a 2.44 ERA across 10 starts.

Meanwhile, Pfaadt (5.31 ERA) has one of the worst advanced profiles in MLB despite the fact that the D-Backs are 15-15 in his starts this season.

The young right-hander ranks in the fifth percentile in expected ERA (5.75) and the second percentile in expected batting average against (.304) this season. He also ranks in the eighth percentile in barrel percentage and the 12th percentile in hard-hit percentage.

The D-Backs and Giants are both firmly in the mix for a wild card spot, but I lean with San Francisco in this pitching matchup. The Giants have lost four in a row, but I’ll back them to turn things around in this series finale. 

Pick: Giants Moneyline (-108 at DraftKings)

---

Odds refresh periodically and are subject to change.

If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.

Claim the latest DraftKings promo code offer today. Sign up and place a $5 bet to earn a guaranteed $200 in bonus bets plus over $200 off NFL Sunday Ticket. Regardless of the outcome of your wager,DraftKings will add eight $25 bonus bet tokens to your new account and award one promo code for a discounted NFL Sunday ticket subscription.