NFL ATS Betting Predictions and Picks for Every Game in Week 2 (Lions Will Cover as Favorites vs. Bears)

The first week of the 2025 NFL season is in the books. We're in the thick of things now as we approach Week 2.

We're still a few weeks away from having teams on BYE, which means we have 16 games to watch and bet on this week, including a Monday Night Football doubleheader. In this article, I'm going to give you my spread pick for every single game. If you want to hear me do a deep dive on all my best bets, you can find them in this week's edition of the Road to 272 Bets.

Let's take a look into my spread picks for all NFL Week 2 games.

NFL Week 2 Spread Picks

All odds listed below are via DraftKings Sportsbook

Commanders vs. Packers Spread Pick

Pick: Packers -3 (-118)

Bills vs. Jets Spread Pick

Pick: Bills -6.5 (-118)

Giants vs. Cowboys Spread Pick

Pick: Cowboys -5.5 (-110)

Jaguars vs. Bengals Spread Pick

Pick: Jaguars +3.5 (-115)

Rams vs. Titans Spread Pick

Pick: Titans +5.5 (-112)

Browns vs. Ravens Spread Pick

Pick: Ravens -11.5 (-112)

49ers vs. Saints Spread Pick

Pick: 49ers -3 (-115)

Bears vs. Lions Spread Pick

Pick: Lions -6 (-110)

Seahawks vs. Steelers Spread Pick

Pick: Steelers -3 (-105)

Patriots vs. Dolphins Spread Pick

Pick: Dolphins -1.5 (+100)

Panthers vs. Cardinals Spread Pick

Pick: Panthers +6.5 (-108)

Broncos vs. Colts Spread Pick

Pick: Broncos -1.5 (-115)

Eagles vs. Chiefs Spread Pick

Pick: Eagles -1.5 (-108)

Falcons vs. Vikings Spread Pick

Pick: Falcons +3.5 (-108)

Buccaneers vs. Texans Spread Pick

Pick: Texans -2.5 (-108)

Chargers vs. Raiders Spread Pick

Pick: Raiders +3 (+102)

Claim the latest DraftKings promo code offer today. Sign up and place a $5 bet to earn a guaranteed $300 in bonus bets plus over $200 off NFL Sunday Ticket. Regardless of the outcome of your wager, DraftKings will add eight $25 bonus bet tokens to your new account and award one promo code for a discounted NFL Sunday ticket subscription.

Odds refresh periodically and are subject to change.

If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.

You can check out all of Iain's bets here!