NFL ATS Betting Predictions and Picks for Every Game in Week 2 (Lions Will Cover as Favorites vs. Bears)

Iain MacMillan | Sep 11, 2025

The Lions are home favorites against the Bears in Week 2. / Daniel Bartel-Imagn Images

The first week of the 2025 NFL season is in the books. We're in the thick of things now as we approach Week 2.

We're still a few weeks away from having teams on BYE, which means we have 16 games to watch and bet on this week, including a Monday Night Football doubleheader. In this article, I'm going to give you my spread pick for every single game. If you want to hear me do a deep dive on all my best bets, you can find them in this week's edition of the Road to 272 Bets.

Let's take a look into my spread picks for all NFL Week 2 games.

NFL Week 2 Spread Picks

All odds listed below are via DraftKings Sportsbook

Commanders vs. Packers Spread Pick

• Pick: Packers -3 (-118)

Bills vs. Jets Spread Pick

• Pick: Bills -6.5 (-118)

Giants vs. Cowboys Spread Pick

• Pick: Cowboys -5.5 (-110)

Jaguars vs. Bengals Spread Pick

• Pick: Jaguars +3.5 (-115)

Rams vs. Titans Spread Pick

• Pick: Titans +5.5 (-112)

Browns vs. Ravens Spread Pick

• Pick: Ravens -11.5 (-112)

49ers vs. Saints Spread Pick

• Pick: 49ers -3 (-115)

Bears vs. Lions Spread Pick

• Pick: Lions -6 (-110)

Seahawks vs. Steelers Spread Pick

• Pick: Steelers -3 (-105)

Patriots vs. Dolphins Spread Pick

• Pick: Dolphins -1.5 (+100)

Panthers vs. Cardinals Spread Pick

• Pick: Panthers +6.5 (-108)

Broncos vs. Colts Spread Pick

• Pick: Broncos -1.5 (-115)

Eagles vs. Chiefs Spread Pick

• Pick: Eagles -1.5 (-108)

Falcons vs. Vikings Spread Pick

• Pick: Falcons +3.5 (-108)

Buccaneers vs. Texans Spread Pick

• Pick: Texans -2.5 (-108)

Chargers vs. Raiders Spread Pick

• Pick: Raiders +3 (+102)

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