NFL Straight-Up Moneyline Picks for Every Game in Week 3

SI Staff | Sep 17, 2025

The Sports Illustrated team breaks down their picks to win all 16 games in Week 3 of the 2025 NFL season. / Sports Illustrated

We're already two weeks into the NFL season, and more than half the SI Team is profitable with their straight-up moneyline picks. Clare Brennan, Mitch Goldich, Conor Orr, John Pluym, and Matt Verderame are sitting in the green heading into Week 3.

Let's take a look at how each person has done so far, and then we'll take a look at everyone's Week 3 picks.

Week 2 Results

• Clare Brennan, Associate Editor 14-2 (+6.41 units)
• Mitch Goldich, Senior Editor 13-3 (+4.82 units)
• Gilberto Manzano, NFL Staff Writer 12-4 (+2.87 units)
• Conor Orr, Senior Writer 12-4 (+3.02 units)
• John Pluym, NFL Managing Editor 11-5 (+1.27 units)
• Matt Verderame, NFL Staff Writer 14-2 (+6.25 units)
• Iain MacMillan, Senior Editor, Betting 10-6 (-0.1 units)
• Peter Dewey, Associate Managing Editor, Betting 11-5 (+0.54 units)

Season-to-Date Results

• Clare Brennan, Associate Editor 25-7 (+8.09 units)
• Mitch Goldich, Senior Editor 23-9 (+4.61 units)
• Gilberto Manzano, NFL Staff Writer 17-15 (-6.49 units)
• Conor Orr, Senior Writer 26-6 (+10.95 units)
• John Pluym, NFL Managing Editor 23-9 (+4.13 units)
• Matt Verderame, NFL Staff Writer 25-7 (+7.19 units)
• Iain MacMillan, Senior Editor, Betting 19-13 (-1.45 units)
• Peter Dewey, Associate Managing Editor, Betting 21-11 (-0.41 units)

NFL Week 3 Picks

All odds listed are via DraftKings Sportsbook

NFL Week 3 moneyline picks. / Sports Illustrate

Dolphins (+575) vs. Bills (-850)

• Clare Brennan: Bills
• Mitch Goldich: Bills
• Gilberto Manzano: Bills
• Conor Orr: Bills
• John Pluym: Bills
• Matt Verderame: Bills
• Iain MacMillan: Bills
• Peter Dewey: Bills

Rams (+150) vs. Eagles (-180)

• Clare Brennan: Eagles
• Mitch Goldich: Eagles
• Gilberto Manzano: Eagles
• Conor Orr: Rams
• John Pluym: Eagles
• Matt Verderame: Eagles
• Iain MacMillan: Eagles
• Peter Dewey: Eagles

Bengals (+142) vs. Vikings (-170)

• Clare Brennan: Vikings
• Mitch Goldich: Bengals
• Gilberto Manzano: Vikings
• Conor Orr: Bengals
• John Pluym: Bengals
• Matt Verderame: Vikings
• Iain MacMillan: Bengals
• Peter Dewey: Vikings

Steelers (-125) vs. Patriots (+105)

• Clare Brennan: Patriots
• Mitch Goldich: Steelers
• Gilberto Manzano: Patriots
• Conor Orr: Steelers
• John Pluym: Patriots
• Matt Verderame: Patriots
• Iain MacMillan: Patriots
• Peter Dewey: Steelers

Colts (-198) vs. Titans (+164)

• Clare Brennan: Colts
• Mitch Goldich: Colts
• Gilberto Manzano: Colts
• Conor Orr: Colts
• John Pluym: Colts
• Matt Verderame: Colts
• Iain MacMillan: Colts
• Peter Dewey: Colts

Texans (+105) vs. Jaguars (-125)

• Clare Brennan: Texans
• Mitch Goldich: Texans
• Gilberto Manzano: Texans
• Conor Orr: Texans
• John Pluym: Jaguars
• Matt Verderame: Jaguars
• Iain MacMillan: Texans
• Peter Dewey: Texans

Falcons (-230) vs. Panthers (+190)

• Clare Brennan: Falcons
• Mitch Goldich: Falcons
• Gilberto Manzano: Falcons
• Conor Orr: Falcons
• John Pluym: Falcons
• Matt Verderame: Falcons
• Iain MacMillan: Falcons
• Peter Dewey: Falcons

Jets (+270) vs. Buccaneers (-340)

• Clare Brennan: Buccaneers
• Mitch Goldich: Buccaneers
• Gilberto Manzano: Buccaneers
• Conor Orr: Buccaneers
• John Pluym: Buccaneers
• Matt Verderame: Buccaneers
• Iain MacMillan: Buccaneers
• Peter Dewey: Buccaneers

Raiders (+154) vs. Commanders (-185)

• Clare Brennan: Commanders
• Mitch Goldich: Commanders
• Gilberto Manzano: Raiders
• Conor Orr: Raiders
• John Pluym: Commanders
• Matt Verderame: Commanders
• Iain MacMillan: Raiders
• Peter Dewey: Commanders

Packers (-485) vs. Browns (+370)

• Clare Brennan: Packers
• Mitch Goldich: Packers
• Gilberto Manzano: Packers
• Conor Orr: Packers
• John Pluym: Packers
• Matt Verderame: Packers
• Iain MacMillan: Packers
• Peter Dewey: Packers

Broncos (+124) vs. Chargers (-148)

• Clare Brennan: Chargers
• Mitch Goldich: Chargers
• Gilberto Manzano: Chargers
• Conor Orr: Chargers
• John Pluym: Chargers
• Matt Verderame: Chargers
• Iain MacMillan: Chargers
• Peter Dewey: Chargers

Saints (+310) vs. Seahawks (-395)

• Clare Brennan: Seahawks
• Mitch Goldich: Seahawks
• Gilberto Manzano: Seahawks
• Conor Orr: Seahawks
• John Pluym: Seahawks
• Matt Verderame: Seahawks
• Iain MacMillan: Seahawks
• Peter Dewey: Seahawks

Cardinals (+120) vs. 49ers (-142)

• Clare Brennan: 49ers
• Mitch Goldich: 49ers
• Gilberto Manzano: Cardinals
• Conor Orr: 49ers
• John Pluym: 49ers
• Matt Verderame: Cardinals
• Iain MacMillan: 49ers
• Peter Dewey: Cardinals

Cowboys (-115) vs. Bears (-105)

• Clare Brennan: Cowboys
• Mitch Goldich: Cowboys
• Gilberto Manzano: Cowboys
• Conor Orr: Bears
• John Pluym: Cowboys
• Matt Verderame: Cowboys
• Iain MacMillan: Cowboys
• Peter Dewey: Cowboys

Chiefs (-305) vs. Giants (+245)

• Clare Brennan: Chiefs
• Mitch Goldich: Chiefs
• Gilberto Manzano: Chiefs
• Conor Orr: Giants
• John Pluym: Chiefs
• Matt Verderame: Chiefs
• Iain MacMillan: Chiefs
• Peter Dewey: Chiefs

Lions (+185) vs. Ravens (-225)

• Clare Brennan: Ravens
• Mitch Goldich: Ravens
• Gilberto Manzano: Lions
• Conor Orr: Lions
• John Pluym: Ravens
• Matt Verderame: Ravens
• Iain MacMillan: Ravens
• Peter Dewey: Ravens

---

Claim the latest DraftKings promo code offer today. Sign up and place a $5 bet to earn a guaranteed $300 in bonus bets plus over $200 off NFL Sunday Ticket. Regardless of the outcome of your wager, DraftKings will add eight $25 bonus bet tokens to your new account and award one promo code for a discounted NFL Sunday ticket subscription.

Odds refresh periodically and are subject to change.

If you or someone you know has a gambling problem and wants help, call 1-800-GAMBLER.